I’ve been on it for 8-9 months, after I had finished radiotherapy. I was terrified before starting because of all the horror stories about having such bad diarrhoea they couldn’t leave the house etc, especially as I had quite a bad tummy at the beginning of chemo. Anyway, it wasn’t nearly as bad as expected. Initially I had some cramps and diarrhoea, especially if I had breakfast followed within a couple of hours with, for example, a milky coffee and croissant. If I didn’t eat too much at once I seemed to be ok. I made sure that every time I went out I had a purse with Loperamide and Paracetamol in it.
I did find that the diarrhoea was quite sudden ie. when you’ve gotta go, you’ve gotta go!!! Sorry TMI.
After 2 or 3 months it settled to about 1 day every 3 weeks of feeling a bit grotty.
I am also on Letrazole and was having quite a bit of pain in the neck and shoulders. They suggested i reduced the Abemaciclib to 100mgs as sometimes the combination of both drugs increases the pain. It’s worked very well!! I’ve also realised that perhaps I had more tummy symptoms than I realised as I’ve had nothing for the last 6 weeks.
Good luck xx