I have a port for Kadcyla. I had a PICC line for 9 weeks during my neoadjuvant chemo as they couldn’t get good enough veins for a cannula (in fact I now have veins which might have permanently collapsed and tissue damage in my arm). The PICC was ok and I was offered it again for Kadcyla but I asked for a port because the weekly flushes, difficulty showering, and inability to swim were all a bit obstructive to normal life. Plus there is a lower infection risk with a port. At my hospital they don’t offer sedation for the fitting and I didn’t feel I could do it with local anaesthetic alone, so they agreed to do it under general. I had my breast surgery in November, port was fitted in December and kadcyla started at the very end of December so a 6 week gap from surgery. My wounds (breast surgery and port fitting) were slow to heal as I had an allergic reaction to the surgical glue, so my kadcyla start was delayed a little. I’ve just started radiotherapy which was also delayed for the same reason.
I’d definitely recommend a port - it does feel a bit funny under your skin but much easier to live with than a PICC. But ask in advance whether they will sedate you while it’s fitted.