Hi there. My partner has been on Kadcyla since February and has had three doses so far. There are many Kadcyla people on this forum who have had varying experiences on this chemo. Many are doing okay and have been able to get back to almost normal work while on this, whereas some are still sort of figuring out what works best for them since the side effects are so varied. I can share my partner’s experience so far. The first Kadcyla was a shock to the system and followed by extreme fatigue, muscle pain and low platelet count. We sort of went to the A&E to be told that the platelet count and liver enzymes were low and high respectively. But she rested it out and was okay resuming normal activities within a week. Also for many people the effects hit on the 3rd or 4th day after the infusion and lasts for 4-5 days. The second and third time around it has been fairly easier for her than the first one. Fatigue, joint pain and mild nose bleeds etc. Bed rest for 3-4 days but the pain is a lot more manageable. She has also been wanting to get back to work full time but the doctors have advised to watch out for another cycle or so on how the body reacts. It is tough for her as she really was hoping to get down to full time work as soon as radiotherapy was done, but we are now just going with the flow. She is also working this out with her therapist because she is extremely angry at this extended chemo, which sort of came as a surprise to us. Having said that, my suggestion would be to just see how to your body reacts to Kadcyla, before committing to your workplace. It solely depends on how your system reacts to it. Also, I know it is easier said than done and you have probably heard it many times, but just hang in there. You will get through this too. The fact that NHS has access to such medicines is something we try to try and feel grateful for. Sending you healing and healthy wishes.