Cryotherapy with topicals

Does anyone know of any trials or treatments available that use cryotherapy alongside topicals specifically flouruoracil and imiquimod?
I have read a paper about 3 cases where this treatment was used with success on patients with cutaneous metastases.
Ive mentioned it to my oncologist but she isnt familiar with the paper & holds to the view that cryotherapy is only really useful for treating pre cancer or cancer that isnt of much depth.

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I have t heard of anyone and I speak to a lot of ladies through various groups. I’ve just done a search on the M2C Facebook group, but there wasn’t much on there on it either. You might need a more experimental onc to do it, but that’s not to say it’s not worth a go. I guess you might need to go private though.x