endometrial, ovarian and breast cancer

Hello, this is the first time I write in this specific discussion forum (although I use the other ones) because until Tuesday I thought there was no history of breast cancer in my family. I had breast cancer with recurrence in 2005 and 2006 (triple negative), I have an aunt who got BC in her 60s and a mother who died of endometrial cancer (at age 62), but a rare an aggressive form, with a cellular type similar to ovarian cancer (serous papillary).
The geneticist told me they would look for a mutation in the BRCA1 and 2 genes, but also in two other genes. Anyway, she said that even if they don’t find any mutation in these genes, she is pretty convinced that this is a hereditary form of cancer, because the endometrial cancer my mother had seems to be related somehow (but not proven yet) to the ovarian-breast hereditary cancer. So there could be mutations in other undiscovered genes. She suggested that I should consider either monitoring or removing the left breast (they only one left), ovaries and uterus.
I am 41 with no children. Although I am not scared (a bit traumatised at the moment!) about doing that (I am prepared to do anything I can to try to avoid going through this again), I am a bit worried about my sister, which, according to this, should consider the same surgeries despite not finding the mutation.
The geneticist is part of a group leaded by a very famous oncologist, so I trust them completely because I know their work, but I wonder if anybody else had a similar experience.

thank you so much for your help!

Hi there

I was diagnosed with BC in '98 when I was 42. My mother had also had BC as had many members of the family. On diagnosis I opted for total mastectomy and 18 mths later was confirmed as having the BRCA1 gene fault. I immediately underwent a 2nd mastectomy and removal of my ovaries. I have now been cancer-free for 9 years. 2 of my 3 sisters tested positive and they both underwent mastectomies (both breasts) and removal of their ovaries and, to date, remain healthy. I felt given all the info available it was the right decision to make and decided against reconstruction-I prefer to wear the silicone in my bra and not under my skin! I have terrible dark days when I feel like a ‘drag queen’ but I don’t regret having the surgery as the alternative is not worth considering. The emotional fall-out though can be tough.

Good luck

Maria
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