I am er+ so will start tamoxifen soon.
On my path report it says er+ H-300
Can anyone tell me what on earth this means? strongly positive or weakly positive or neither??? oncology nurses have not a clue!
Hi V. Hmmm, dunno without asking Mr Google but am seeing JG as Mus tomorrow a.m. so will ask him for you if chemobrain allows me to remember! xx
Erm, no idea! Mine said ER+ 8/8… so cannot possibly figure yours out!!!
Oh…am at musgrove too…10am tomorrow…want a coffee?
Ooo yes, let’s. I’ve got JG at 9.30. What are you doing there?
Hi LIF H-300 is an antibody its a test they do to stain part of the tumour to see if it present or not and i think it gives an indication of family genetics eg BRC1 /BRC2 gene but im NOT sure so ask youre oncologist what it means.The number is not related to it being postive of negative .The ER is a different test (oestrogen receptive)it is measured on a scale of 1-8 ( 8 being strongly positive)
Hi Lostinfrance
Did the report say anything immediately after H-300? If you do a quick Google on it JulieB is spot on when she says it’s a marker they use for BRCA1/BRCA2 genes but presumably there must be a level or threshold for the H-300 result to give cause for concern. For example, “normal” being below 20 and a conclusive positive result being above 50 (I’ve plucked those numbers out of thin air, I’ve no idea what the actual levels might be).
The ER tests can be scored two ways, out of 8 which seems to be more popular or out of 300. Funny, had that discussion with my onc last week. X
Tina45 - I thought it was written as a fraction out of 8 or out of 100 - i.e. as a % not out of 300?
Jane xxx
Scoring for ER Immunostains:
(a) Conventional scoring: The immunohistochemical localization of ER scored in a semi quantitative fashion incorporating both the intensity and the distribution of specific staining as described by Mc Carthy, Jr et al.4 The evaluations shown as percentages of positively stained tumour cells in each of the five intensity categories denoted as zero (no staining), 1+ (weak but detectable), 2+ (mildly distinct), 3+ (moderately distinct) and 4+ (strong). HSCORE was derived by summing up the percentages of cells staining at each intensity multiplied by the weighted intensity of staining. An HSCORE of less than 50 was established as negative, between 51 to 100 as mild (weak positive), 101 to 200 as moderate (intermediate positive), while 200 and more as strong positive.4
(b) Allred scoring: In addition, Allred score which is semi quantitative system that takes into consideration the proportion of positive cells (scored on a scale of 0-5) and staining intensity (scored on a scale of 0-3). The proportion and intensity produce total scores of 0 or 2 through 8. A score of 0 -2 was regarded as negative while 3 - 8 as positive. I found this on one of the pubmed extracts.
Hope this may by helpful. X
Ah Ha…
No not BRACA results as daughter being tested as they want youngest living person with bc and work backwards apparently…!
It was after my WLE that they wrote down the results and it says…
ER+ - H-300
PR-
HER2+ FISH
So I assume its the same as what Tina45 discussed with her onc and I’m 8/8 or 300…or something ???
Will ask yet again tomorrow…Mr google has not got a lot of intelligable info!
How confusing having two different ways of stating how ER+ you are. As if everything wasn’t already confusing enough!
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And what on earth is FISH to do with HER2!?
Thanks chaps…knew you lot would know more than the ‘experts’ xx
xx
.
I think FISH must be another acronym…!
Hi Lif,
Fish is how they test for herceptin, I learnt this at forum (see, i was listening)fluorescence in-situ hybridization (FISH)
Sarah.xx
Thought it must be the herceptin test…now I know what it stands for…I am getting such an education on this site…thanks Sarah xx