Hi eve+exe ladies!
I’m in my first week of this combo, and for now no SE.
After how long they show up?
I read it work better on people with more SE, than in people without…is it true?
I hope it will work without SE!!
Any more succes stories? I’m so worried in this period…
Anyways good luck, as slways! Have a good weekend!
Hi Amel . How are you doing on the EE combination . I think I’ll be offered it next Monday bas my third line of treatment- Ribociclib/ Fulvestrant and Cape all having failed rather quickly .
Hi
Look like we did similar lines of therapies.
I did ribociclib+letrozole, Capecitabine, and EE. It worked for 5 months, keeping things pretty stable, and with not too many sides effects (mouth sores, and skin rushes). I did an MRI to my liver about 25 days ago and thigs were allright with some small improvment too. So I was really happy.
Unfortunately 5 days ago I had a sever food poisoning and since than i stayed so bad, as much as two days ago i end up in urgent care, and I’m now still in the hospital. Now I have some ascites, and my liver enzymes are super high. So I’m really worried. They told me I probably have a liver infection, and they put me on antibiotics…i’m already way better, with no fever and appetite again.
But I’m so terrified of a liver progression!
But hopefully it is just the infection causing all this…
Anyways other than that, until a little ago, things were allright, and I excaped chemo for few more months.
So I really hope I can keep staying on this med until some other possibility will arive!
(For the mouth i was using desametasone mouthwash and for the rush Gentalyn beta cream, and things were very menageable!)
If my liver wouldn’t have this high numbers and i had a progression i would of look at the trial VELA, with the cdk2i Blu-222. It look like a promising drug that is used for cancer that progress on cdk4/6. It appear that targeting together cdk2 and cdk4 can win cdk4/6 resistence.
I’m not sure if they have that trail where you live, or you may just want to give a look in case EE will fail in the future. I think you are may be eligible because I was, and we have a similar history of meds. I also would of be eligible for Capivasetib, but unfortunately is not approved yet here in Italy.
I’m er+, pr-, her2 neg (0), with no other common mutations like PI3K, esr1, etc…
Long message…anyways I hope it will work for you, with not too many SE, best wishes!
And if you have more questions I’m here!
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Thanks for that - helpful and I’m sorry you’ve ended up in hospital. Hope things improve soon .
I will see what my oncologist says on Monday - she suspects I have a nasty cancer cell that is not going to respond to anything . No treatments actually stopped progression thus far although the progression would have been faster without ,
I may come Monday decide to draw a line on active treatment , live free of side effects and hopefully get just a few months to still get out and do what I can ( which isn’t much - age alone doesn’t help!). I’m 18 months on from diagnosis and thus far no liver mets only bone although my spine is getting worse definitely.
But nothing will be easy and I try and focus on one day at a time .
All the best - I see you live in Italy ? My last and best holiday to celebrate being 70 was to Tuscany - fabulous .
Tuscany is beautiful, what a nice place to celebrate!
Bone only disease is actually considered the less dangerous of all, may be you can also ask for local radiotherapy? Sometimes can help. And in the meanwhile they may approve something more effective with no many SE, that’s always my hope.
My liver value are little better, I hopefully can go home today to my husband and kid!
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