For Christine MH.

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For Christine MH.

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For Christine MH. Hello Christine I was looking for a thread you posted on and just cannot find it. It was an answer you gave in which you mentioned it’s more important to be PR+ than ER+
As I’m strongly positive for both I was interested to know why the importance of PR+?
Best Wishes, Belinda…xx

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Ooops Hi Belinda,

I double checked and what I wrote is no longer right. ER+,PR+ still does the best, but aromatase inhibitors are so good for ER+,PR- (50% reduction in recurrence versus 20% for other hormone receptor types), that it is almost as good as ER+,PR+ according to the results of the ATAC trial, which were announced in 2004.

I guess I should just stick to ER-,PR-,HER2+ 3+.

Sorry.

Christine

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Hi! Hi Christine, thanks for the reply and the other post was useful as it led to a couple of us discovering off forum that not everyone is checked for their PR status.
Belinda…x

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Christine Hi, I’m interested in this too, where have you read about the research findings?

Thanks

Sandra

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Pr +ve Thought I’d read something recently by (?) Prof Smith at the Marsden
that the role of Pr+ve and HER2+ve still remains controversial when choosing the optimal hormal therapy. (sorry can’t remember where or find the reference)

There was a paper presented at SABCS where the benefit of Letrozole appeared to be better in Oest+/Prog+ that Oest+/Prog-. (but as already posted ATAC showed benefit in the Oest+/Prog-)

Think this is another area where there is still a lot of research/learning to be done.