Has anybody had a genetic test which found a variant?

Hello ladies

I have recently had a new genetic test called myriad myrisk which looks at 25 Genes linked to cancer. I already new my BRCA test was negative but because my sister had breast cancer at 28 and I had it at 45 I was offered this test (luckily paid for by our health insurance) . Although no mutations were found a variant of unknown significance was found in a gene called ATM which is linked to breastcancer. I am told that there is not enough research/data to prove if this caused my breastcancer and therefore will be filed until more information becomes available, I just wondered if anybody else that has had a genetic test has discovered a variant like this ? And did you do anything about it? Thankyou Michelle xx

Hi Michelle

Whilst you are waiting for the other users to reply with their experiences you might find it helpful to talk things through with a member of staff on the BCC helpline.  Here you can share your thoughts and concerns with someone who will offer you a listening ear as well as emotional support and practical information.  The number to call is 0808 800 6000 and lines are open weekdays 9 to 5pm and Saturday 10 to 2pm.

Best wishes Sam, BCC Facilitator 

Hi Michelle

I have had bc and been tested for the BRCA genes - both I and another family member (who also had bc) tested negative for BRCA. However both been told that with family history there quite probably is a genetic link (but in a gene not yet identified rather than BRCA) and that some other family members are at higher risk of bc than the norm and should go into screening programme early. No specific variant identified but I was told that due to family history I might get asked if I would participate in future genetic research studies - and in fact this has just happened. Let’s hope that research can pin down some more of the problem areas.