Hi @sim1 and welcome to the forum. I’m sorry you’re having a rough time especially on a much needed holiday. All I can offer is that I’ve been on Letrozole (essentially the same as Anastrozole) for 2y 8m but have had two drug holidays for different reasons, one for 6 weeks and one for 10 weeks in agreement with my BC nurse. I am in my late 60s. My SE are different to yours (all manageable) but all of them abated after about 5 weeks on the breaks. Obviously I’m not medically trained but it sounds like you could be having panic attacks, particularly if you’re regretting not have your tablets with you. Perhaps putting this question to our nurses here Welcome to Ask our Nurses might help if you can’t get any help where you are. It is very disappointing for you to feel so poorly on holiday but in my layman’s viewpoint, I can’t imagine that clinically not taking the drug would make you feel worse, I certainly enjoyed the peep above the SE clouds on my breaks. Good luck in getting some answers.