interesting review on “Chemo Brain”
interesting review on “Chemo Brain” Nature Reviews Cancer 7, 192-201 (March 2007) | doi:10.1038/nrc2073
Candidate mechanisms for chemotherapy-induced cognitive changes
Tim A. Ahles1,2 and Andrew J. Saykin2,3
Abstract
The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function.
will quote this!!! am going to quote this when family accuse me of having lost my marbles! my memory and skills have definitly deteriorated since chemo two half yrs ago.Its good to have some info on this.thank you
sharonx
That’s really cheered me!
Taffy if you can remember it all there’s nowt wrong with your memory or cognitive function [from your reaction]!
dilly