Hi - sorry that your first Kadcyla was so awful. I get the nausea & sickness. My neo-adjuvant was docetaxel & carbo. - that for me was brutal. Extreme diarrhoea & vomiting. Vomiting finally managed by daily Ondansetron, diarrhoea beat everything. But it was only 6 cycles; but would NEVER want to experience again. Your current nausea looks to be like my diarrhoea experience. Hope that hospital stay will get you back on the level & find something to quell the nausea. Pls keep talking to your team. They donāt let you suffer where itās seriously effecting health & well being. Theyāll explore all alternatives, including reducing dosages, changing regimes etc. I did experience random bouts of exhaustion - after 3 cycle generally had 1 day per cycle that I just slept like a baby - 15hrs! Also went through a mud section with increased muscle, joint, & general pain. Got a prescription for paracetamol & for some time added 8tabs to my daily meds. Rattling away. I found that the underlying side effects remained until last cycle (12), but at very variable & unpredictable levels. At the end June 2023, felt like my body had aged 10yrs & I was generally not healthy. The good news is that I am now cancer free & in remission. Health has recovered. Stamina back & im working on strength & flexibility with daily exercise. If you have someone on your team that you feel ācloseā, & opening up works I found that despite the number of patients they can identify us & connect. Keep posting, we are here to listen, support, hopefully do what we can to help your resolve. It hits all of us differently & each cycle is different. If you have the strength, maybe try cycle 2 & here is 
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Thanks so much for replying!
Sounds like youāve had it rough too, but it is a relief that the side effects havenāt been so bad with 2 & 3. Hereās to an even better 4th cycle for you.
I have spoken with my team and they were aghast that I had been so ill, questioning whether Iāve had the flu at the same time which is entirely possible with two kids who like to bring home plenty of germs!
Iām so thrilled that this has worked for you and you are cancer free. What a feeling that must be!
Youāll be in my mind when I go for my next cycle at the end of January. My team are reluctant to reduce my dose and are querying whether Iāve had flu or something else underlying.
How rotten is docetaxel? I was allergic to it which nearly wiped me right out!
Iāve gotta go back for cycle 2 - my surgeon said he wants me around for at least another 40 years so I canāt disappoint him after the amazing job he did of my reconstruction!