Hi, I’ve been taking Amitriptyline to help with nerve pain and insomnia. Ive been on letrolzole since mastectomy in 2021. I’ve been told I likely have Glaucoma (waiting for appointment with eye consultant)… Sorry long story. I’ve been told amitriptyline can worse glaucoma. I need help to sleep. Do you know if I can take herbal Nytol with letrolzole? I know it contains. valerian, passion flower and hops. Thanks Erica

Hi @dotegor

Thank you for posting your question. It sounds like you’re having a difficult time at the moment.

Glaucoma can be a side effect of amitriptyline, so it is understandable that you would like to know about other options to help with your sleep. You may find our information about sleep disruption helpful to read.

Many people ask about vitamin and herb supplements as they want to do as much as possible to be healthy and manage any symptoms they have. There is often the belief that vitamins and herbs are safe as they are considered natural.


There is much we don’t know about supplements and herbal remedies. Herbal treatments don’t have to comply with the same regulations or rigorous testing that conventional medicines do. For many products there is a lack of research to support their use, and some can interfere with conventional medicines including cancer treatments such as letrozole.

You can search this American website, Memorial Sloan Kettering Cancer Centre, for information about the individual herbs in Nytol. Each has sections on existing evidence and what known interaction there is with other medications. You may find that that some herbs have different names in America. You can also search herbal products and supplements on the American website Medicine Plus

Do speak to your treatment team, GP, or a pharmacist before taking any supplements. It’s not clear if the nerve pain you mention is related to your breast cancer surgery, but do mention this to your treatment team as well as they may be able to advise on other ways to manage and improve this.

We offer a range of free supportive services for anyone who has had a diagnosis of breast cancer which you may be interested in. They include face to face and online courses and events.

For more details about all of these services, please see the information on the link.

Please do call our helpline if you would like to talk this through or have any further questions. The helpline team have time to listen to your concerns, talk things through and signpost you to more support and information. Your call will be confidential, and the number is free from UK landlines and all mobile networks. The number is 0808 800 6000, (Relay UK -prefix 18001).

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Best wishes


Breast Care Nurse

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