Hi jaynealis,
Thank you for your post. It is understandable you ask about medication to help manage the hot flushes you are experiencing whilst on Letrozole.
Some antidepressant drugs like Paroxetine can help reduce hot flushes for some women. Antidepressants can be prescribed in a lower dose to help with hot flushes than when prescribed for depression, and so you are unlikely to have an antidepressant effect.
As you mentioned, Clonidine which is normally used to treat high blood pressure can also be used for managing hot flushes and may be effective for some women.
You may find it helpful to contact your breast care nurse or treatment team about and speak to them about your concerns. They can talk you through other ways to manage your hot flushes, like complimentary therapy or cognitive behavioural therapy. You could also ask to be referred to see a menopause specialist and talk through the side effects you are experiencing since stopping HRT.
Our Breast Cancer Now chats: Menopause & breast cancer - Oct 2025 may be helpful to watch. Menopause and Cancer is another resource you may find of use for further information on managing menopausal side effects as a result of treatment.
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