Tamoxifen and depression

Hi Scotland 16. I’m due to have radiotherapy in the next couple of weeks and my oncologist told me that it can burn the skin. I was told by another BC lady and my friend who is a Cancer Nurse to only use baby products on my skin and to put suncream on my exposed skin even though it is Autumn because they could burn my skin during treatment.
I am feeling weepy and sad on Tamoxifen and I’ve only been on it for 2 weeks. Does it matter whether it’s taken at night or in the morning. I take it at night. I was told by the oncologist that it courses weightgain and it sure does. I’m also finding my knees are stiffer and I’m slower in walking.

Everyone is, of course, different and will react to treatments differently. Just got to do it and hope for the best.


I have had rads twice with no issues, just told to not go sun bathing for a few months. And I was on Tamoxifen from 1999 to 2009 then back on it Jan 2017 both times with no side effects.


I’ve been lucky as it’s been an easy ride so far and a long one coming up to 19 years. Was only 26.


Good luck and stay positive!




I recently got out of a psychiatric hospital after having been on Tamoxifen for over 2 years. I was experiencing depression unlike any I have had before, and when I started having suicidal thoughts, I called my neighbor and had her take me to the local ER. They took one look at me, asked a few questions during which I could not stop crying, and arranged for me to be transported to a hospital. 

     I mentioned to the doc there that I suspected that my symptoms have to do with the Tamo, but he sort of dismissed that, and put me on Effexor after I had told him that when I had tried SSRIs in the past for situational depression, they had a negative effect on me. The Effex made me more depressed, so, after consulting my oncology counselor and having her tell me that it was ok to lay off of the stuff ‘for a while’ I went off of it, and within a week, I was feeling human again, after 10 days, I am back to being my old self. I felt that the psychiatrist did not have any experience with this problem, maybe now he has. 

  I can’t tell you how awful I was feeling for close to a year, the symptoms getting much worse so that my summer was a disappointment, and by early Oct., between crying at the drop of a hat, joints aching, having no energy, and becoming obsessed with the idea of ending my life because I could not stand to feel the way I did anymore, I was a mess. Ultimately, I had diagnosed myself, and the hosp. stay, while relaxing, was probably unnecessary. If my onco doc had told me up front that depression was a common side effect and that if I experienced any such symptom to discontinue its use I would not have panicked and I would have simply stopped using the Tamo, avoiding all of the drama and expense to the ins. companies. 

So…just a thought for those of you who may be in the same sitch. 

Hello Rudy ,welcome to the forum .Sorry to hear you are suffering - it’s horrible to feel
so low .Hopefully once your body has adjusted to the Tamoxifen you will feel better .It could also be that now things have quietened down your brain is processing all that you have been through ? If things don’t settle down or get worse you need to get some advice .Hope you feel better soon ??? Jill

Some signs help us know the perspective of the person. These signs enable us to understand that a person was facing depression. These stand as symptoms which helps in analyzing the mindset of the patient and also link removed, through which situation that the person is going through.