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Baffled by science!

4 REPLIES 4
Member

Re: Baffled by science!

There is a soluble bisphosphonate which you could try (apologies - I can't recall the name) if not already?  it's meant to be better for the reflux SE.

The best things you can do for your bones is a good healthy diet and weight bearing exercise.  Bisphosphonates are a triumph of pharma marketing to some extent.

Member

Re: Baffled by science!

Hi Frances333  I was also prescribed 2 different bisphosphonates  both of which caused gut pain diarrhea and dehydration, my doctor referred me to rheumatologist and he has prescribed Denosumab  for me. I was told that because of my history of ulcerative colitis and long term steroid treatment subsequently resulting in having an ileostomy this is why I am probably unable to tolerate bisphosphonates. As I have got osteoporosis  of the spine and osteopenic  hips  and taking anastrozole for invasive grade 3 bc  and oestrogen positive my rheumatologist  said denosumab  would be the best option. First injection is on 1st August so fingers crossed for not too many side effects. By the way I am also the same age as you.  Best wishes Fezzy1952

Member

Re: Baffled by science!

Thank you that was interesting. I am hoping Denosumab is the one for me as reading all the side effects etc it has the least problems. My only concern was it not being a bisphosphonate. Despite that according to that article it looks good for oestrogen and HER2 positive cancers.

thank you for posting the article.

 

Frances x

Member

Re: Baffled by science!

It seems like Denosubat's a pretty good option in your situation. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30862-3/fulltext

Member

Baffled by science!

Good morning.

I was diagnosed with IDC, 8mm, stage 2, HER2+ and Estrogen 8 August 2017. Sentinel nodes clear.

no chemo just 15 fractions radiotherapy. I’m currently on Anastrazole and Adcal D3. Had a dexa scan at same time of diagnosis and I am osteoporotic. I’m 66 now so post menopausal. My GP has tried me on 2 bisphosphonates orally. Side effects were awful. Main cause being acid reflux which I’ve suffered from for 12 years anyway and these made it worse. Have been referred to rheumatology with the intention of having them either venous or subcutaneously to bypass stomach. I also suffer from Atrial Fibrillation. I’ve been without cover for 3 months which my GP has worked hard at to get sorted. Out of the blue I received a call Friday saying to go Monday for rheumatology appointment. Funny how a letter from GP saying The original 6/8 month wait was not on for me changed things. 

I have done as much research as I can as rheumatologist reply to GP was suggesting either Zometa or Denosumab but will decide when I’ve been seen. 

Denosumab isn't a bisphosphonate albeit that it’s good for bones. All my reading has suggested that bisphosphonates may  have a slight potential to help stop recurrence of BC into bones in post menopausal ladies. Some say only if started as soon as diagnosed or BC is aggressive. I’m classed as low to moderate risk of recurrence. Would have been low risk except for the HER2.

 

Can anyone please shed any light on BC and bisphosphonates and whether Denosumab is just as good. Want to go with as much information as I can tomorrow. I might see someone lovely who has up to date information or I might see someone who is writing a prescription before I sit down kind of thing.

 

Many thanks and hope everyone will enjoy this lovely sunny day.

 

Frances xxx