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Combining Tamoxifen and Zoladex, yes or no?

3 REPLIES 3
Member

Re: Combining Tamoxifen and Zoladex, yes or no?

Hi,
I’m on tamoxifen since February 18, and zolodex since September 18.
I’m 40. The percent increase in survival I was told was probably 2-5% which when my odds of being here in 10 years was 50% it seemed to be enough to give it a go. I was very reluctant but, to be honest it’s not been that bad. It just intensifies the hot flushes for a week after the injection. No joint pain or any new issues. Give it a try - you can always stop again after a couple of months if it’s not tolerable x
Member

Re: Combining Tamoxifen and Zoladex, yes or no?

Hello kjtm/Optimisticmz
Same here. On Zoladex and tamoxifen. Diagnosed March 2015, mastectomy, chemo and rads. I was on tamoxifen initially and then my periods re-started, about 8 months after chemo. I was put on zoladex four months later. I have been on it since September 2016. I have been on 3 monthly injections for about a year. I was 41 when diagnosed. I have tried to find research that supports this combination too and think It is SOFT/TEXT trials, but someone else on here might know better. I can’t say I notice any additional side effects from tamoxifen alone, but I’ve been on it a while. I also want to know how long I will be on it, but guessing my menopausal state is still uncertain until I come off.
Hope info helpful
Member

Re: Combining Tamoxifen and Zoladex, yes or no?

Hi Kjtm

 

I am on tamoxifen and Zoladex. I am a bit older than you and was peri menopausal when I was diagnosed in September 2017. I dont really know the statistics but my oncologist was very keen for me to take Zoladex. My understanding is that it puts you in a medical menopause within 3 weeks! Initially I had nausea and heavy legs (hard to say if side effect from Zoladex or Tamoxifen). I still have hot flushes and leg cramps (controlled by taking magnesium tablet) and everything is manageable. I also get a low mood sometimes but think thats the Tamoxifen. I have the zoladex injected by a nurse at my Doctors practice. Its a bit painful (sorry) but you get used to it.

 

Hope this helps & if you would like to know any more then let me know. Michele

Member

Combining Tamoxifen and Zoladex, yes or no?

So my onc is saying standard treatment is Tamoxifen and Zoladex together to prevent or lessen chance of reoccurrence. I'm 39 years old, diagnosed at 37 had bilateral mastectomy, chemo and rads. I have been taking tamoxifen for the last 1 1/2 and have joint pain, mild hot flashes and no period. The side effects listed for zoladex sound terrible and I'm not sure how much more of myself and body I can sacrifice!?! Do the benefits of adding Zoladex outway the bad?? Does anyone know the percentages?? Up until this point I have refused the Zoldex shots but my onc is really pusing for them. I would love to hear everyone else's experience around this issue
Thanks 🙂