67370members
354934posts
cancel
Showing results for 
Search instead for 
Did you mean: 

Kadcyla didn't work

4 REPLIES 4
Highlighted
Member

Re: Kadcyla didn't work

Hi Nicky

Yes I am hoping for surgery to happen and maybe they can clarify if I am still HER2 positive. So crafty it can change when it comes back. I feel for you that you have had similar to me in drugs not working 😞

 May I ask what treatment you are on now and how you are coping with it.

X

 

Highlighted
Member

Re: Kadcyla didn't work

Thank you Angel eyes.

I did wonder if the Liver Met has changed so maybe HER2 receptor is no longer positive! I have just heard from my oncologist, hoping I can have surgery of some sort to remove from Liver, praying this will happen , after that not sure what will happen, probably back to horrible systematic chemo 😞

x

 

Highlighted
Community Champion

Re: Kadcyla didn't work

Hi katherine

I agree with Angel Eyes, maybe see if you can get a biopsy done? I know it can be difficult to get to some lesions in the liver but it may be worth asking about. Also, as you talk of a liver met(singular) do you have any others in the liver? It is worth asking about more targeted treatments such as RFA (fashion frequency ablation) or surgery? I know when I had my resection a couple of years ago the large liver lesion they removed, when biopsied, was shown to be triple negative - something I’d never shown to be including any biopsies had. No wonder it had not responded to the hormone treatments I’d been on but had shrunk previously on chemo.

Wish you well

Nicky x

Highlighted
Member

Re: Kadcyla didn't work

Hello Katherine, 

My thoughts are with you.

I'm new but wondered if it might be possible for you to be re-biopsied? Maybe the HER-2 receptor status has changed?

Don't know if it will make any difference even if it was the case? (not sure how it all works - if Oncologists are allowed to 'go back' on a drug that has not worked before - if you see what I mean?)

I'm sure other members will know the answer.

All best, 

Angel Eyes

Highlighted
Member

Kadcyla didn't work

Hi wondering if anyone is in similar position, I have bone and lung mets that have been stable for a few years with Capecitabine and Herceptin. I am ER/PR negative HER2 positive. A scan in Feb this year showed new met in Liver, taken off Cape & Herceptin put on Kadcyla, first scan after 4 cycles showed Liver met increase, so taken off Kadcyla, really scared now.