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Classical CMF- cyclophosphamide tablets- any experience?

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Re: Classical CMF- cyclophosphamide tablets- any experience?

Thanks xx

Re: Classical CMF- cyclophosphamide tablets- any experience?

Here is a list of side effects of oral Cyclophosphamide:

 

"SIDE EFFECTS: Nausea, vomiting, loss of appetite, stomach ache, diarrhea, or darkening of the skin/nails may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. If these effects persist or worsen, notify your doctor or pharmacist promptly.Temporary hair loss may occur. Hair growth should return after treatment has ended or may even return during treatment. However, new hair may have a different color or texture.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: pink/bloody urine, unusual decrease in the amount of urine, mouth sores, unusual tiredness or weakness, joint pain, easy bruising/bleeding, stopping of menstrual periods, existing wounds that are slow healing.Tell your doctor immediately if any of these rare but very serious side effects occur: black/bloody stools, severe stomach/abdominal pain, yellowing eyes or skin, dark urine, mental/mood changes, muscle weakness/spasm, swelling of the ankles/feet, sudden or unusual weight gain.This medication may rarely cause very serious effects on the heart, especially when used in high doses, or in combination with radiation treatment or certain other chemotherapy drugs (e.g., doxorubicin). Seek immediate medical attention if you develop: chest pain, jaw/left arm pain, trouble breathing, irregular heartbeat.This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills or persistent sore throat.Cyclophosphamide may lessen the chance of having children in both men and women. Sterility is usually temporary with this medication, but can be permanent in some cases. Consult your doctor for more details.Although cyclophosphamide is used to treat cancer, in some patients it may increase the risk of developing another form of cancer, sometimes months to years after treatment. Consult your doctor for more details. It is important to be closely monitored by your doctor during treatment. You should also see your doctor regularly after treatment is finished. Tell your doctor immediately if you develop: unusual growths or lumps, swollen glands, unexplained or sudden weight loss, night sweats, pain in the pelvis, painful or frequent urination.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects."

 

It's a bit long, but thought it might help. xx

Re: Classical CMF- cyclophosphamide tablets- any experience?

Thanks ladies, yes Gadgetgirl the C and F are the same drugs-,only the methotrexate is new ( poems galore, good point that could be the culprit but I had it IV). The main 'new' thing I'm worried about is the cyclophosphamide cos I get it in tablets for 2 weeks - rather than the one off IV. The literature doesn't give a lot of help as to whether that's more likely to induce nausea - it kind of makes sense to me that it might as it's going in via your gut but I'd be keen to hear how others found the tablets. It's very weird to be taking my own chemo at home this time with these tablets..,,Thanks again for commenting x

Re: Classical CMF- cyclophosphamide tablets- any experience?

I think it is more likely to be the Methotrexate in CMF. It is a horrible drug. I used to have 25ml injections every week for RA. Had to move to injections as the tablets made me nauseous, and have dizzy spells and blackouts. 

 

Best wishes

 

poemsgalore xx

Re: Classical CMF- cyclophosphamide tablets- any experience?

Re: Classical CMF- cyclophosphamide tablets- any experience?

Hi, the C in FEC is cyclophosphamide so you've had that before. I think the F in FEC and CMF is the same too, but not sure. BCC has lots of useful info on the different chemo regimes so you can find out exactly what you're on and what the side effects are. I'm sorry you're feeling so rubbish, you could call your BCN tomorrow, they should be able to help you get some stronger/different anti-sickness meds. Jo x

Classical CMF- cyclophosphamide tablets- any experience?

Hi I'm day 3 of this chemo regimen- I did 4 FEc and 4 Tax over autumn/winter and feel much more nauseous so far on this than on FEC despite the anti nausea meds I have. I'm worried this could be the cyclophosphamide tablets and that I will have horrible symptoms for the whole 14 days I have to take them. Any experience of this welcome! Thank you