I had 3 FEC and 3 Docetaxol with herceptin, for me the very first FEC I was very very sick that night. I thought the male nurse had a funny look on his face when he asked me did I suffer from morning sickness? which i did! After the first one they corrected my sickness meds and I coped really well, no tiredness, just a heady feeling of being drugged.i did get slight nausea on FEC even with anti sickness,but it passed after a day, I ate dry cream crakers, (weird but it helped!) and anything else like constipation or sore mouth,heartburn, you can get med for those. I walked lots throughout my treatment as I found the fresh air and exercise helped me through! I would say that side effects were cumulative but only mildly for me fortunately I was lucky, I think staying as fit as possible is the key! good luckxx
I'm currently having a course of 6 x FEC-T. I've done my 3 x FEC and just had my first dose of T last week.
I found the fatigue cumulative through the FEC, and by the third cycle, I just didn't get any energy back before I went on to have my next chemo session.
Changing to T is different though. I don't know what to expect with this yet. I felt fine for a couple of days after having it, then got severe aches and pains on days 3 and 4, but feel a bit better again this morning (day 5), so I don't know what's coming next.
I think the more times you have the same drug or drugs, the effects accummulate, but changing to a different drug changes the goalposts, if that makes sense.
I know I'm one of the lucky ones because i haven't had ANY nausea or neutrapenia. But I have suffered a lot with mouth ulcers and lost fillings, so it is swings and roundabouts, I guess.
You really just have to get on with it, phone the cancer nurses or your GP if you get a side effect that needs a prescription and don't suffer in silence.
I had a different chemo regime (3 x FEC and 3 x Tax) and was unable to work due to risk of infection in my particular line of work and general fatigue.
However, to answer your question... I kept a daily diary of how I felt and generally I tolerated each cycle rather better each time around with less severe side-effects and more energy each time. So, for me, chemo did not get worse.
I hope it continues to be not too bad for you.