There are now I believe starting to be other alternatives to herceptin (pertuzumab?) but I understand that the NHS has decided not to use it which is a bit of a bummer! Glad the capecitabene is working well for you Nicky - that's good to hear. Its ages since I've been on here, really nice to hear from you! xx
This happened to me. Dx er+ in 2004, Her2 neg in 2007 (I asked for the test, Her 2 testing as a matter of course did not begin until a while after my initial dx.). In 2008 I was dx with recurrence in chest lymph nodes, initially assumed to be similar to primary but luckily my onc put in for the her2 test on the recurrence and it was strongly positive. So thankful that he did. I had herceptin for 17 cycles. I always say to people with a second dx that it may be different from 1st - insist on a check.
Hi, thanks for link to the review article. I've skim-read the article (but not clicked on any links to the original research papers). But I'd like to raise a point, to clarify.
The article mentions "circulating tumour cells", presumably in the blood. This sounds straightforward (having a blood sample taken is no big deal), but it doesn't always give useful results if the patient is (or has recently been) on an effective treatment. It's also been suggested that metastases should be biopsied...hmmm... to be honest I'm not keen on the idea of having my bone and liver mets biopsied!
It is a question that I intend to raise with my oncs soon, especially if my current treatment stops working.