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ER Pos Recurrent patients retesting for Her2

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Re: ER Pos Recurrent patients retesting for Her2

There are now I believe starting  to be other alternatives to herceptin (pertuzumab?)  but I understand that the NHS has decided not to use it which is a bit of a bummer! Glad the capecitabene is working well for you  Nicky  - that's good to hear. Its ages since I've been on here, really nice to hear from you!  xx

 

 

 

 

 

 

 

 

 

 

 

 

 

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Re: ER Pos Recurrent patients retesting for Her2

Yes, it happened to me as well. Primary in 2003, ER and PR very strongly positive, but no HER testing carried out at that point. Recurrence (and bone mets )in 2008 which tested the same with the HER status being checked at this time, shown to be negative for HER+ Further progression of bone mets and into liver earlier this year. I requested a liver biopsy and, yes, I'm now ER and PR +ve still, although not as strongly PR, but also HER + Unfortunately due to a heart problem I can't at the moment have Herceptin, but the Capecitabine I've been on since Feb is still working well.
Nicky

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Re: ER Pos Recurrent patients retesting for Her2

 This happened to me. Dx er+ in 2004, Her2 neg in 2007  (I asked for the test, Her 2 testing as a matter of course did not begin until a while after my initial dx.). In 2008 I was dx with recurrence in chest lymph nodes, initially assumed to be similar to primary but luckily my onc put in for the her2 test on the recurrence and it was strongly positive. So thankful that he did. I had herceptin for 17 cycles. I always say to people with a second dx that it may be different from 1st - insist on a check.

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Re: ER Pos Recurrent patients retesting for Her2

Hi, thanks for link to the review article.  I've skim-read the article (but not clicked on any links to the original research papers).  But I'd like to raise a point, to clarify.

The article mentions "circulating tumour cells", presumably in the blood.  This sounds straightforward (having a blood sample taken is no big deal), but it doesn't always give useful results if the patient is (or has recently been) on an effective treatment.  It's also been suggested that metastases should be biopsied...hmmm... to be honest I'm not keen on the idea of having my bone and liver mets biopsied!

 

It is a question that I intend to raise with my oncs soon, especially if my current treatment stops working.

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ER Pos Recurrent patients retesting for Her2

<p>Hi...I am high risk, with a friend just diagnosed with recurrent ER pos BC after nine years. If your initially ER positive Her2 neg breast cancer returns, several studies indicate u may want to test your new mets for Her2. The second timevaround, they may test pos for Her2, which means you can consider one of the very good anti-Her2 drugs out there. Please see the peer reviewed article: "Her2 and Breast Cancer Stem Cells: More Than Meets the Eye," or read the below lay article that has links to more peer reviewed articles on this subject to show clinicians? Good luck.


http://www.dddmag.com/articles/2013/08/more-breast-cancer-patients-should-take-herceptin-studies-hin...