Hi Jay, This is horrible news to get about your mother,however the treatment for this has advanced so much that she will do well. Have faith in the medical team. Sometimes being node negative makes us feel that the cancer has not spread however as your mum has found out it can travel blood vessels. The main thing is that she has a cancer that can be treated and treated successfully. Herceptin is a wonder drug and if that does not work there are other drugs which can be accessed. Good luck for the future and give your mum my regards. Be positive.