This differs from person to person. You just have to see how things go after the first dose. Usually, the same pattern is followed every time. I didn't feel any nausea at all. Had my treatment on Thursday, and was fine until Monday when there was a dip in my energy and felt 'wiped out' By Tuesday I couldn't function at all, but still managed to go shopping etc. This fatigue and feeling 'out of it' lasted until late Friday, then by Saturday I was reasonably ok again - except for constipation/diarrhea, and sore mouth. But onco gave me meds to counteract this. Odd thing, I kept telling the chemo nurses I didn't need the anti sickness meds but they kept giving me them. I never used them so have boxes of the stuff in my cupboard. Maybe you should let someone else take care of her (if she needs it) the first time. Sending hugs and best wishes.