I'm another who had a PICC line. It's one of those things which look worse in advance than they really are. I had no pain with the insertion and only a little discomfort after it was first in. They recommended paracetamol and a warm hot water bottle for discomfort. I also got a cheap sleeve meant to go over a cast and kept that arm away from the shower--in some ways a bath was easier because I just propped that arm on the edge.
I did find that my clothing sometimes caught on the fittings, but someone on the forum suggested wearing a stretchy but not tight sleeve over the top. (This was winter, and I was wearing lots of jumpers because our central heating was dying.) I got a light one from the hospital and also used lengths of large tubi-grip.
I live near the hospital, so they recommended coming there every week for cleaning and flushing, which just took a few minutes. It also makes the blood tests much easier. The nurses were good about using different sized plasters to minimise skin irritation, which tends to be a problem for me. At the end, it was removed before I realised it was happening and I can scarcely find the mark now, 2 years after.