Can anyone tell me what crib form and micropilliary means as this showed on biospy result with Atpical ductal hyperphasia
Cribiform means a holey pattern to the cells. Micropapillary means small wart like. Both can be found in low grade dcis as well as adh so they normally want to remove the adh surgically and look at it under the microscope to ensure no dcis is present… However treatment for both adh and low grade dcis is the same namely wide local excision.
not sure if this will will make much sense to you…
http://surgpathcriteria.stanford.edu/breast/dcis/printable.html
But if you read the abstract of this research article you will see that these can be indicators for LGDCIS
http://171.67.112.51/content/131/1/112.full
this is the type of abnormality which has been in the news recently about possible over treatment… If you are older then it possible it would never actually develop in your lifetime but if you are younger and have many years ahead of you then why take the chance.
good luck
Thank u so much lulu, for taking the time to explain. My first biospy showed ADH but the wider biospy showed flat atypical to cribform and micropilliary cells. No disease found. So they have sent of to professor in London for a second opioion to confirm AdH or dcis. Has its a wide area a masectomy was mention by me more than specialist. Im only 36, this was found because of a injury cause me to have pain in the same area. Can you still be diagnosed with dcis if no cancer cells are found or are the cribform and micropilliary the cancer cells???
Hita Hay
DCIS would normally have malignant cells. But atypia is the bottom end of a range of abnormal cells where as malignant cells are at the top end. Cribiform cell patter may be malignant or just atypical… There are other cell types which apear more with DCIS like comedonecrisis. you can also get papillary lesions which are benign or intraductal papillary lesions which is dcis. Im not a pathologist but this is just what i have picked up… But i know that in a very small percentage of adh has to be upgraded to dcis… But it would normally be low grade dcis and as i said the treatment is normally the same regardless.
ill be keeping my fingers crossed the prof can confirm Adh though.
xx
Just an update, called breast clinic on Monday to ask if biospy result was in from the 2nd opinion from a professor and my name on list to talk about in group meeting.To make the confirmation of Atpical ductual hyperhasia or DCIS. As second lot of biospy found flat atpical to cribform/micropilliary.
The breast care nurse said they will call yesterday once they had there meeting together and get me into clinic today.But nothing no call yesterday or today. Should I be worried or is no news good news. I did mention as its a wide area I would prefer a mastectomy. Would they be sorting this out or could they have found something more! Really worried but don’t want to phone.
Any ideas what the delay could be.
HI Hay123
Sorry didnt see this earlier or I would have said phone them - they don’t mind being called. If they have not rung by 12noon tomorrow I would ring them anyway. Try to call before 12.30 as they usually go for lunch around 1pm.
Best of luck - hope it is just ADH but if it isn’t then DCIS is not the end of the world either. At least they have found it and are doing something about it 
Best wishes
Liz x
Hi hay
its possible they just didnt have a conclusive answer… Occasionally it takes a bit longer to actually get the final result… But that said if they said they would phone then they should have done so even just to say they dint have any info yet.
if they havent phoned yet you give them a call and chase them up. Fingers crossed.
lulu x
Hi got confirmation today with high grade dcis, need to have sential node biospy, next week. How likely is it to show positive. Feel totally devastated. Any advice :-((( mastectomy and reconstruction aswell.
hay im sorry to hear its shown dcis… i would presume though your SNB will be neg… we wouldnt even check here… if after surgery they identify an invasive tumour they would go back and do an snb… but i cant imagine they are considering an invasive tumour when they werent even sure it was dcis… its possible they are doing it because your having a mastectomy and i presume your having reconstruction and if your getting a recon it makes it a bit more difficult to go back and do an SNB.
only a tiny proportion of DCIS ops will show a focus of invasive bc… if tehy are already doing an snb then its unlikely to alter your treatment.
xxx
Thanks lulu. Just make me worry that every time I go it gets worse. Don’t really understand high grade. I know cells were cribform/micropilliary. Do you knowif high grade DCIS has more recurance even though having mastectomy .
The chance of getting a recurrence after a mx having had high grade DCIS is 1% which is the same chance as anyone getting cancer. (My oncologist told me this when I asked!)
All the best
Liz x