Hi I was told that there is about a 1% risk of getting womb cancer whilst taking Tamoxifen. The benefit of Tamoxifen for most far outways the risk of getting womb cancer. Also if womb cancer does develope then it is almost always really early and can be cured by surgery. I finished 5 years of Tamoxifen some months back and had a bleed in November, I'm 51 and don't know if it is periods back or not. Anyway I went to GP who referred me to gynecologist . I had internal ultrasound which showed thickening of the womb and a simple cyst on my ovary. I then had a hysteroscopy and biopsy of the womb. Maybe this would of happened anyway or maybe it was the Tamoxifen. My BC was 8/8 eostrogen and progesterone + so well worth the risk in my opinion 🙂 x
I also had endometrial cancer while on tamoxifen, after about 3 3/4 years on it. I had had endometrial thickening too but had a hysteroscopy and biopsy when I suddenly started getting really heavy bleeding. The biopsy showed a type of endometrial hyperplasia but by the time I had a hysterectomy it was stage 2 (b I think) endometrial cancer (this was about 5 months after me reporting symptoms, due to delays between hospitals and consultant holidays), It was a huge shock at the time but after the surgery and radiotherapy I have not had any further problems with that. Sadly the breast cancer did come back though and I have bone and chest wall secondaries.
I'm still glad that I took tamoxifen, as I feel that in my case it probably delayed the appearance of secondaries by several years. But it's good to be aware of the small risk of endometrial cancer and to get any unusual bleeding checked out.
I had womb cancer from Tamoxifen and quite early on. I had only been on the Tx for 2.5 years. i was very aware that Tx could cause endometrial ca. so I asked my oncologist for a pelvic ultrasound to check the thickness of lining of the womb. It discovered thickening. I then had to have hysteroscopy followed by another one 3 months later in which a small tumour had grown. Had keyhold hysterectomy and it was all at the earliest stage 1a. In fact they didn't find any ca. at the op. Think it had been scraped away at the hysteroscopy. Not pleasant but all bearable and I am lucky I had the forethought to get myself checked. It could have been much worse.
Anybody worried at Tx and womb cancer, ask for pelvic ultrasound. Gracet
It does seem to be tricky to find any precise data on this (at least from reputable websites) but I have seen figures of 2-5 times the risk of women not on Tamoxifen being quoted.
There is a thread in the 'hormone therapy' section of the 'going through treatment' board which I started when I had suspected endometrial hyperplasia (thickening of the wall of the womb) a year ago; I recently posted on there again as I am in the process of having a second incidence of this investigated (relatively unusual). Although that thread doesn't have any frequency/incidence data quite a few women have shared their stories, so it may help with information gathering. http://forum.breastcancercare.org.uk/t5/Hormone-therapy/Tamoxifen-Induced-Endometrial-Hyperplasia/m-...
Basically, I was told that any spotting or bleeding should be reported straight away to my GP. NICE guidelines say that you should get a 2 week referral due to increased risk of cancer (SIGN differs slightly). I have been assured that should cancer be detected it would be treated curatively with surgery.
Not sure if that helps. You could also look at CRUK e.g. here http://www.cancerresearchuk.org/cancer-info/cancerstats/types/uterus/incidence/uk-uterus-cancer-inci... and here http://www.cancerresearchuk.org/cancer-help/type/womb-cancer/about/womb-cancer-risks-and-causes#tamo...