Thanks for replies. I have switched from Letrozole to Tamoxifen. Think the extreme post-menopausal effects, including dry vagina and loss of libido are less. And it's not as bad for your bones. Had my annual follow up where I was told a different aromatase inhibitor would have been their second choice, presumably in terms of keeping cancer at bay. But I feel better and will take my chances on that.
Thanks - another advantage of Tamoxifen, that it is OK to use topical oestrogen if needed.
My oncologist said I could have Ovestin cream to deal with the dryness problem, but only if I'm taking Tamoxifen, not on Letrozole, because of the different way the drugs work.
The Ovestin puts a very small amount of oestrogen into your system, but apparently this is OK with Tamoxifen because that stops it binding to any stray cancer cells which may still be lurking in your body.
I've found the cream a huge improvement, I'd just about gone off sex altogether, but now it's comfortable and fun again.
I had loss of libido (no desire for sex, no orgasms) on Letrozole; symptoms improved when I stopped for 2 months and returned when I restarted so I am sure it is that, not just being postmenopausal. I have been offered Exemestane (Aromasin) or Tamoxifen as alternatives (or of course I could stop taking anything and increase the risk of recurrence/death). Anyone got any suggestions as to which anti-oestrogens have least effect on libido? Thanks.