progesteron receptors have changed after neo-adjuvant treatment ?

[Bevlaar]

sorry...this posted before i had finished....meant to say these ladies have now reached 10, 12 and 13 years without recurrence. So dont worry. Youll probably be fine. My friends were all really shocked when this happened to me as I was the one out of all of us with the best prognosis!!
Who can tell ?
Wishing u well and big hugs 🙂
love bev xxxx

[Bevlaar]

Hi mrey300.
I wouldnt worry too much about the node involvement. I had bc first in 2005 then a new primary in 2009. Both times had clear lymphnodes...but decided on axillary clearance the second time just to be doubly sure!
Last month was dx with secondaries in lung despite being given an excellent progmosis with very low risk of recurrence. Yet I have friends who have had bc around the time i had my first primary, one had 18 out of 23 nodes pos, the other had 8 out of 11 pos. another had 3 and another had 4.
None of these ladies have ever had a
recurrence....and they have reahged 10 yrs,

[Desi-2]

Hi mrey 300 my progesterone has never been mentioned only ER and HER so maybe it won't make much difference xx

[mrey300]

Hi all,

I just received my pathology report and its been shocking.

19 cancerous out of 22 lymph nodes involved with extracapsular spread.

Over 7 cm mixed lobular/ductal grade2.

After neoadjuvant chemo EC+Taxol my ER+ 8/8 PrG+ 8/8 changed to ER+ 8/8 PrG- 0/8

Why could my progesteron receptors have changed?

Could it lead to a worse prognosis?

How optimistic should I consider such 19/22 lymph involvement?

All replies appreciated.