I just received my pathology report and its been shocking.
19 cancerous out of 22 lymph nodes involved with extracapsular spread.
Over 7 cm mixed lobular/ductal grade2.
After neoadjuvant chemo EC+Taxol my ER+ 8/8 PrG+ 8/8 changed to ER+ 8/8 PrG- 0/8
Why could my progesteron receptors have changed?
Could it lead to a worse prognosis?
How optimistic should I consider such 19/22 lymph involvement?
All replies appreciated.