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Endocrine therapy for 3/8 ER


Re: Endocrine therapy for 3/8 ER

Hi Bdunn

Thanks for posting. It sounds as if you’re facing some difficult decisions about your endocrine therapy.

It’s also understandable that you want to make the right decision, based on the risk of side effects of hormone therapy and zoladex, balanced with the benefits.

It’s not possible for us to make recommendations for an individuals’ situation.

However, based on the criteria for the Allred scoring system, the percentage of positive oestrogen receptors indicates that a score of 3 out of 8 is positive.

As Yolande55 suggests, many women take tamoxifen with few problems of side effects.

You don’t say what age you are, or your menopausal status, which may affect your decision making.

It would be a good idea to contact your specialist team again to discuss your concerns. The oncologist could add your details into an online tool, such as Predict, to give you a result of the benefit you’d gain from the  options offered to you.

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Re: Endocrine therapy for 3/8 ER


if it helps I’ve been taking Tamoxifen for 3 months with hardly any side effects. Another of my friends had been taking it for 9 years and also no side effects.

Good luck with your decision 



Endocrine therapy for 3/8 ER

Hi, I was diagnosed with IDC III, HER 2+, ER 3/8, PR 0/8.  Initial biopsy showed ER 3/8 from lower outer breast and ER 0/8 from lateral biopsy.  Having final chemo this week(have had mast and clearance during Covid crisis), 3 weeks of Rx starting in 4 weeks and targeted therapy for a year.  I didn't factor in endocrine therapy until last week when my Oncologist brought it up for the first time as my ER was 3/8.  On all correspondence, my ER status is ER negative to weakly positive.  Basically, the decision on whether or not to commence endocrine therapy has been left up to me.  

I have been doing some research and from what I can determine, endocrine therapy is not very effective in those with a 3/8 ER allred score.  From what I can see my options are:

1. Accept that any score above 2 is positive and endocrine therapy should be taken

2. Endocrine therapy is unlikely to be effective with an ER of 3/8 and considering the well documented reports of nasty side effects, it may not be worth it

3. Commence endocrine therapy and if the side effects are unbearable then reconsider whether these outweigh the possible benefits of remaining on such therapy

I'm finding it very difficult to reach a decision, my main concern being that I could start a medication/medications that carry the risk of clots and stroke when the drug itself my not benefit me at all.  I've been told my options are Tamoxifen alone, Tamoxifen with Zoladex or aromatase inhibitors with Zoladex.  

I would appreciate any feedback please.