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Re: Re-biopsy?

Hi @Guest user 

Thanks for posting.  

It’s understandable to have questions about your breast cancer and treatment when you have been told that one of the tumours in your lungs is growing while the rest of your disease remains stable.   

It’s difficult for us to comment on individual situations and say whether a re-biopsy would be of benefit to you. It’s also not possible to say if a biopsy was performed, what the results would show. Your treatment team would be best placed to talk through your recent scan results and what the next steps may involve.   

You mention that you are currently on the CLEOPATRA trial. Being part of a clinical trial means following the trial protocol.  Your breast care nurse, research nurse or treatment team can discuss with you any treatment options that may be suitable for you.    

We provide a number of different services for people living with secondary breast cancer aimed at providing both information and support.   

Our helpline team are here for anyone diagnosed with secondary breast cancer. They have time to listen to your concerns, talk things through and/or signpost you to more support and/or information. 

At times like this, some people find it helpful to talk with others who are going through a similar experience.   

We have a secondary breast cancer online discussion forum for sharing information and support.  There is also a weekly Live chat session which runs on Tuesdays at 8.30-9.30pm.    

Both services allow people to talk over their experiences and offer support to each other.    

To ensure people still have access to support and information whilst our face to face sessions are suspended, we have developed our Living with Secondary Breast Cancer Online programme and virtual meetings.  

The programme enables you to access specialist information and share experiences, understanding and support with people who are also dealing with the uncertainty and challenges that secondary breast cancer brings.   

Our face to face Living with Secondary Breast Cancer monthly sessions also give you the chance to meet and share experiences with other people who understand what you’re going through because they’re going through it too.  

Do call our Helpline if you would like to talk this through or have any further questions. Your call will be confidential, and the number is free from UK landlines and all mobile networks.         

The number is 0808 800 6000, (Relay UK -prefix 18001). 

If you would like a nurse to call you do complete this form. Ticking the box agreeing to a call back.   

Our opening hours are Monday to Friday 9am - 4pm and 9am -1pm on Saturday. Out of hours you can leave a message and we will call you back when we next open.    

Best wishes   


Breast Care Nurse   

Please read the Ask Our Nurses disclaimer  Full details on how we collect and use your data can be found in our Privacy Policy   

This thread will now be closed from further replies. If you have any additional questions or would like to provide feedback, please start a new thread. 

Guest user
Not applicable



One of the tumours in my lungs is growing. 

The rest of my disease is stable on a combination of Herceptin and Perjeta (now Phesgo). My Consultant is reluctant to take me off good drugs but has warned me she will have to bring on Kadcyla if the growing tumour has 'tendrils' which radiotherapy cannot target.

I am waiting to find out from Radiology. I forgot to ask my Consultant if it would be worth re-biopsying the said tumour? I am strongly HER+ and follow the Cleopatra Trial protocol. I am scared Kadcyla won't work and have been on Herceptin and Perjeta for one year. I was hoping to get a bit longer out of it.

Am I right in thinking that as I am so strongly HER2+ that if the tumour has changed receptor status, it can only be to TN? Is it possible to receive chemotherapy to target one tumour, concurrently, with the Cleopatra Trial protocol? 

Am I asking the right question: is a re-biopsy relevant? 


Angel Eyes x