hi this happened to me also. I had been on capecitabine for 2 years then has progression to bones and liver. Docotaxel did nothing in fact the liver tumours grew whilst on it. I started Kadcyla in april and have had 2 scans that show stable but not sure how long that will last may be worth asking about it. I was told it can only be used when all other treatments have failed. Good luck
Thank you Nicky for your reply. I did question my oncologist about possibility of different receptor status. I had a liver biopsy before my treatment began and it did show that I was still hormone positive her2 positive, its 2 or 3 lesions that have grown slightly so maybe they are different? I'm just hoping the letrozole has a good effect!
I haven’t had this happen myself but just wanted to say how frustrating and disappointing this must be after 6 cycles of chemo. Quite often when a treatment is more targeted to a particular receptor this can happen as it is possible to have different types of Breast Cancer present at the same time because it can mutate. I know this happens as I am classed as hormone positive, HER2 negative but at times have shown to be HER2 positive and, when I had my liver resection done the lesion was triple negative. However with chemo I think it’s more unusual. The good news is the tumour markers have dropped a lot and the follow on treatment should continue that trend.
Maybe someone else will have more experience of this and be able to help but just thought I’d reply.
Forgot to add, my bloods showed a dramatic drop in tumour markers from over 800 before treatment began to under 400.
I've recently finished 6 cycles of docetaxel after being diagnosed with mets to lung, liver and low volume to one hip and rib. A scan a week after finishing chemo showed some progression in liver and a 2mm progression on lung. Obviously my oncologist and myself were disappointed with this, he said some of cancer is under control but clearly some isn't. I am continuing on herceptin and perjeta which I had along side chemo anyway and I've just started letrozole. Has anyone else been in similar situation?