KI67

[Beatit]

Hello lovemama, 

Thanks so much for the resources you sent. 

Very interesting read indeed. X

[Beatit]

Hello Jan,

Thanks for the reply. I did the mistake of googling the sh*t out of everything and its a very scary place there. But since meeting and talking to many people with SBC I have come to realize that the stuff out there is outdated so that's good to know. I stayed "cured" for 18 years and now its back. What medication are you on? And how do you manage side effects? I may be able to relate as a fellow 70 yo. I'm already in pain from the letrozole(cipla) I've been taking. I have not been given any inhibitor like pablo etc. I dont know why. But this one medication has me down already (along with zoledronic acid and calcium). I'm still waiting for my HER result.

[lovemama]

HI Beatit,

You may find the information about KI67 proliferation index  from below link.

https://www.breastcancer.org/symptoms/diagnosis/rate_grade

Your may find the correlation between chemo/delay chemo/no chemo and KI67 proliferation index from below link.

https://www.nature.com/articles/d42473-021-00301-5?fbclid=IwAR21RcNLHuGOYeZAJLsdOLz79yrVu8yyGXdyd82v...

[Jaybro]

Hi

Love your choice of name! Speaking as another 70 yo newbie (March), I broke my own rule as I wasn’t Googling for myself and established the K167 is a protein linked to metastasis and is used as a diagnostic and predictive indicator. It’s not yet another score that sounds alarming.

So yes, it will help your MDT decide the best treatment for you. Secondary bc is a horrid diagnosis but there are more and more treatment options and much higher success rates than even a decade ago. Personally I prefer not to know all my data - it just sets alarm bells ringing - so I rarely read the detail of any reports sent to my GP and don’t ask to see scan reports etc. There’s more peace of mind fr me that way. But others need to know everything to feel in control. It’s a choice you can make now, before treatment starts, because seeing cant be undone. 

I wish you all the best

Jan x

[Beatit]

Newly diagnosed with extensive bone mets including lung and lymph. 70 yrs old. Only on letrozole and zoledronic acid. Still waiting for HER2 results. My report says KI67 around 40% . What does this mean? What is this index measuring? Is it used to decide the treatment plan?