My oncologist is hoping to get me on the nab plaxitaxol/ immunology (atezalibumab) for triple neg secondaries in my nodes. I'm currently waiting for the PDL1 test results. They have been delayed because of the all the Corona virus chaos. I was hoping to get on a trial of CT7001, the Carrick trial some people on here are calling it. Unfortunately its for people who have already had one line of secondary chemo and I've had nothing so far as only just diagnosed recently. My oncologist did say that he's heard that the results on that trial are good so far, so maybe some hope for the future for us with TNBC and few treatment options. It's good to hear that you have done well on nab plax and immunotherapy. Are you still on it? I'm not sure what kind of risk I'm running with chemo at a time of pandemic but if I do nothing its going to spread. No choice really. At least I'm in a smaller city, Exeter, not London, and can isolate easily. Thanks for your reply and I really hope you are doing ok where ever you are
i think current approaches for mTNBC are to save the harshest treatments for later and do the less hard ones first. What is your oncologist recommending?
my oncologist (the second opinion one) always said that with this disease it was better to get the right treatment rather than to rush in. Go get that second opinion.
Thanks for your reply. I'm new on here so don't know anyone, and just fumbling my way around whilst still in shock and denial after my recent diagnosis. It's good to know that that this chemo and immunotherapy combo has worked for you, and long may it do so.
I was one of the lucky ones on my primary treatment 2 years ago, the FEC worked and shrunk my tumours right down and I had few side effects until the last. So now I'm worried that all the bad stuff is going to head my way with treatment for secondaries. With a diagnosis right at the beginning of this Coronavirus pandemic, it does feel sometimes like my luck has run out big time! Still, I'm OK so far, and determined to do what I can to carry on. I've always been pretty resilient.
My big question, given that various chemo drugs usually stop working as the CA mutates, is should I have the hardest chemo first or save that till later on? When I saw that there was a trial open of a drug CT7001 that might control TNBC without harsh side effect, like hair loss and neuropathy, I thought that might be a good one to try while my CA is low volume.
I'd like to have a second opinion from a specialist in TNBC. I saw that you posted on this topic and I've worked out who the consultant is so will try to arrange a video consultation if poss. When I told my oncologist about the CT7001 trial, it was obvious that he knew nothing about it. He's very helpful, but we TNBC are a pretty rare breed and we can't expect that generalist oncology services will be offering us the most suitable therapy. I don't even know my BRAC status and there are now more targeted drugs if you have that mutation. I wish I'd got the test when I was diagnosed. I was pretty naive and thought I would be able to beat it. Down to earth with a bump now!
Anyway, thanks and good luck. I hope you are keeping safe and have plenty of help. These are crazy times for all of us. If you have any advice about anything, I'm all ears. x
just to say I am on nab plaxitaxol and immunology (atezalibumab) for triple neg secondaries and would recommend it. I’ve done well on it and been well on it. It is very tolerable and nothing like the heavy duty chemos given for primary breast cancers. Get it if you can.
Hi,I’ve been on Palbociclib and Anastrozole for almost 2 years.
I am not TNBC, that’s why I was asking the question because most people seem to be TNBC. I am ER+. I have multiple mets in my spine and pelvis.
Expecting a call from the nurse running the trial soon.Hopefully I’ll know more next week.
Thanks for replying 🤞x
Yes, it's the Carrick trial. I don't know if I qualify. Sorry to hear your treatment has stopped working. Are you a TNBC? How long have you been on your treatment? The whole thing is scary, but its good to support each other on these forums. I hope this new treatment works for you, it does seem to be quite cutting edge. I'd send you a hug but I'm new on here and have no idea how to do it. Best wishes. x
Is this the Carrick trial.?
I have just been told that I qualify for this but I am unsure what to do.
My Palbociclib/anastrozole treatment has stopped working according to my latest scan results. Very scared at moment as not on any treatment.
Hi I've just joined and I'm looking for options for treatemnt for TNBC secondaries in nodes. just diagnosed earlier in the week so my life has been turned upside once again. I was just back to normal after full on treatment and was 2 years post treatment then mammogram and biopsy really brought me back to earth with a bump. Onc wants to put me on Pax and immunotherapy, but I'm not sure I can go through that again. This trial looks interesting. Is it working and how do you feel on it? Good I hope. I'm just worried about getting on it with all the corona virus measures making travel difficult and hospitals going into melt down. What a time to get this back again, I could scream, but trying to stay calm and research my options. Any advice would be really welcome. x
Hi Not sure where you are with treatment. I've started CT7001, only last Friday so a novice. Ive been chasing secondaries in my Liver since March 2018- I had two lobes removed, chemo then Thermal ablation but Im triple negative and its persistant. Surgery isn't an option but the trial offers hope if not promises
I am on carrick triel triple negative in nodes 2 affected both were 1.4 now after 1st scan 1 node gone to 0.6 other gone to 1.6 was worried but they said nodes are not as easy to measure coz they can flatten change shapes so they said I have had a 24% reduction and asked coz its grown maybe it's how they measure it on ct
Thanks Lovemama for your reply. I am not going to be doing this trial because of prior treatment so don’t fit the protocol. I had kinda made the decision not to do it anyhow as Not expecting to be in this position, we have a lot planned over the next few months. It is my intention to do all that is planned and being on such a trial wouldn’t have fitted with that. I am going to take whatever treatment I am offered initially and see how I get on. Ironically I had been on the Pallas trial for the last 18 months so was taking palbociclib alongside tamoxifen then later letrozole. Like most people the Palbo played havoc with my neutrophils. I am back at the hospital on Monday so hopefully will have a clearer idea of my treatment plan going forward. Then we are off to Tenerife 🌞. Not looking forward to telling my hol ins about the secondaries! But so looking forward to leaving the C word behind in the UK for at least a week or so.
Hi WMJ, are you sure you are given CT7001 and Fulvestrant. It s just my understanding CT7001 can be a treatment for ER+ and TN while Fulvestrant is for ER+ only. By reading your previous posts, look like your BC is TN ??
Anyway, if you are finding T7001 for TN. You may go to section Secondary Private Group and search for CARRICK trial. A lady was on it.
PS. I am NO medical. Just I remember there is the thread CARRICK trial and did some googling it is about a trial for CT7001.
Hi, You May have seen my other post, recently diagnosed with secondaries.
I am looking at some trial information I was given yesterday and wondering if anyone has started this or is thinking of doing so?
Thanks for any contributions x