Stopping Paclitaxe

I have been on Paclitaxel since the end of August 2020. Unfortunately I have struggled with side effects and although some of the lesions on my liver have decreased in size, some have increased. It is so strange how that happens. I assume it is to do with where the legion is in the liver and blood supply to it.  The long and the short of it is in view of me struggling with SEs and it not doing what they had hoped the ONC is looking at another option. Anyone been in this position? Prior to Paclitaxel I was on Capecilabine and fulvestrant, unfortunately without success.

I was first diagnosed with ER +ve, HER2 +ve in November 2016 and then metastatic in bones & liver Oct 2019

jayne x