Hi, I have been on Tamoxifen for 2.5 years now. I also had awful aching legs (thighs) - mainly at night. Sometimes cramps too but I think this is separate. Someone in another forum recommended taking Clarentin (Loratadine) each day. Yes this is usually for sinus or allergies and it sounds bizarre, but it definitely works for me. Takes a few days to kick in but now my pain is 80% gone. I almost didn’t believe it so I tried going off it, and within a few days, the pain was back. There are a few studies online if you google it showing that it can aid with muscle pain / DOMs. Try it out.
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