I've had secondary disease for 3 yrs. My primary diagnosis in 2014 was oestrogen +ve HER2 negative. My secondary presentation was in the lymph nodes above the clavicle, triple negative. I've had several different chemo regimes, with spread to pleura, pericardium, liver and bones. Liver biopsy two year ago was HER2 +ve oestrogen negative, (treated with herceptin/perjeta/doxetaxel). Bioply of my pleura four months ago was triple positive! I'm now on Kadcyla and Letrozole, which has improved my pleural effusion and pericardial effusion, but neck lymph nodes have worsened, so I've recently had radiotherapy. How common is it to have different types of secondary breast cancer cells simmultaneously? My consultant told me there is no protocol to treat both HER2 +ve and HER2 -ve at the same time, is this correct?
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