Breast Cancer Care Forum

Just to share. The below document is done by BC cancer agency of Canada Provincial Health Authorities   http://www.bccancer.bc.ca/family-oncology-network-site/Documents/New%20Approaches%20in%20Breast%20Cancer%20Treatments%20-TShenkier.pdf ... View more

So far I know Dendritic Cell Therapy has already been available in Japan for 1-2 years. (probably Germany as well, from the chatting on UK research forum and now, Taiwan. When is the therapy in UK and Canada ?? The below article has been converted from Chinese to English by Google Translate ps. When I search for Dendritic cells UK, I found below.  https://www.evidence.nhs.uk/search?q=Dendritic+cells When I search for Dendritic Cell in Canada, I found this... year 2024.....8-( 8-( https://www.canadianinsider.com/dendritic-cell-cancer-vaccine-market-2024-clinical-insight-of-3-marketed-vaccines-clinical-pipeline-of-63-vaccines *********************************** Taichung City, China Medical University attached to the hospital, spending more than 100 million yuan to build the first "cell therapy center" approved by the Ministry of Health and Welfare in Taiwan, officially launched on the 18thJune, for the solid cancer stage 4 patients, autoimmune "dendritic cells "Treatment, together with the tumor "co-cultivation", to further eliminate cancer cells, will bring the gospel to eight kinds of cancer and cancer patients in China. Cai Changhai, chairman of the China Medical University and Medical System, pointed out that Chinese doctors have been studying cell therapy for more than 10 years and have established a GTP core cell operating room that meets the criteria for human cell therapy clinical trials. There are physicians who have the qualifications for cell therapy prescribed by the Ministry of Health and Welfare.30 patients, who meet the admission criteria, from local and abroad consulted related treatment courses. According to Zheng Longbin, CEO of the Cell Therapy Center, "dendritic cells" are one type of autoimmune cells with "identification" ability. The patient is separated by blood conduit output and co-cultured with autologous cancer cells to make "dendritic cells." The vaccine is injected into the patient's body; it activates the immune system and activates the "T lymphocyte" function to attack and eliminate cancerous tumors to achieve therapeutic effects. The 36-year-old man surnamed Chen, who camefrom Hong Kong to Taiwan for medical treatment in Taiwan, had a large tumor of 11 cm in the previous year due to hepatectomy. He was treated with chemotherapy and target drugs. He metastasized lung cancer in less than half a year and healed after receiving "dendritic cell" treatment. The hospital said that the current "dendritic cell" treatment needs to be paid by the patient at its own expense, between 1.8 million yuan and 2.55 million yuan. Autoimmune "dendritic cells" are directed against glioblastoma multiforme, and secondary brain tumors (brain metastases), epithelial ovarian cancer, pancreatic cancer, prostate cancer, head and neck cancer, liver cancer, breast cancer, and Eight kinds of solid cancer patients, such as colorectal cancer, and the fourth stage of solid cancer patients received the case and treatment; future stem cell and arthritis and other stem cell treatment plans have been sent to the Ministry of Health and the Ministry of Health, after the approval will benefit more patients. ... View more

  Just to share. This page has been converted from Chinese to English by google translate. ps. I am a diabetic and have been prescribed metformin for 15 years since my daughter was born. 1000mg daily. Honestly, I did not take it regularly, maybe, <10 in a month until my second diagnosis. I am not sure whether it has helped in my cancer treatment journey. My experience there is no adverse effect of this med but it has to be administered by medical professionals as it may cause low blood sugar which is dangerous.  **************************************************************************** Liao Zhiying, MD    2019/9 Updated Director of Radiation Oncology, Taichung Hospital, Weifu Department New York MSKCC Cancer Integrated Medicine training Houston MD ANDERSON Cancer Integrated Medicine training   Old drug new role Metformin, an old diabetes drug, has been researched in cancer prevention and treatment in recent years. In general, people with diabetes have a twice-risk chance of developing cancer, but epidemiology has found that cancer patients have diabetes. Among people, those who use Metformin have a cancer mortality rate of 15-57%, through the possible regulation of insulin (increased sensitivity), gradually reduce blood sugar, reduce inflammation, reduce cancer cell division and angiogenesis. To reduce the deterioration of cancer cells.   Research mechanism  Metformin affects the growth and reproduction of cancer cells through: Reduce blood glucose in the blood by reducing glycogen breakdown, and increase the insulin sensitivity of the cells (reduce insulin resistance) Reduce blood insulin, reduce the Ras/Raf/MEK/ ERK and PI3K/AKT/mTOR signal transmission pathway stimulated by lysin in cancer cells, reduce cancer cell division and growth Metformin directly stimulates the AMP-activated protein kinase pathway to inhibit cancer cell mTOR (some target drugs also inhibit mTOR). Retrospective literature: A.cancer prevention Meta-Analysis 18 studies analyzing 560,000 people, reducing the incidence of cancer by 27% B. Retrospective study of cancer treatment 1. Prospective cohort in the Netherlands -1353 Diabetes cancer patients use metformin to reduce 57% of cancer deaths 2. Canada 10309 retrospective observations (retrispective) reduce cancer death by 20% 3. Systematic review (Meta-Analysis) 28,671 people, observational studies reduced 35% of deaths, clinical trials did not.   Clinical Trials: At present, clinical trials (lung, endometrium, breast cancer, etc.) are still in the test. Can query : ClinicalTrials.gov multiple bundles combined with other target treatment, chemotherapy and radiation therapy, and is a potential radiotherapy sensitizer.   Breast cancer: Two-day randomized study before surgery, 47/39 patients, using metformin before surgery,  post-operative examination shows Ki67 split index significantly reduced. (General Ki67 is used to observe the rate of cancer cell division, the higher the score, the faster the division. Non-diabetic breast cancer patients, HOMA (insulin resistance index) > 2.8 use metformin, can reduce Ki67 tumor division coefficient Blood sugar drugs reduce breast cancer  ki67 35-->29 from biopsy to surgery, slowing the growth of cancer cells. Celebrex (anti-inflammatory drugs) also slowed down the cancer cell division index ki67 by 29% before surgery Endometrial cancer: 1.Metformin blood glucose drug reduces the cancer cell division index to 67% from biopsy to surgery.   Lung cancer: JAMA Phase II Clinical Trial Lung Cancer Target TKI combined with blood glucose (metformin 1000mg) to prolong Median OS survival (31.7 months vs. 17.5 months)          The latest JAMA study in 2019~Hot   to sum up: Metformin is the first line of diabetes medicine, which may prevent cancer or adjuvant treatment of cancer by reducing blood sugar, reducing insulin secretion and AMPK/mTOR. Currently, preliminary clinical human studies can slow the growth of cancer cells (using the Ki67 indicator). Especially in the insulin resistance but not in the diagnosis of diabetes patients, the use of target drugs for lung cancer, combined with the use of metformin in the initial study, there is an increase in survival, and in the future, a larger randomized clinical trial test is needed to confirm the effect. Reference MD ANDERSON Metformin in Cancer Treatment and Prevention Annual Review JCO 2014 Annals of Oncology 2016 Celebrex breast cancer trial 2018ASCO Lung Cancer ... View more

Just to share. The page is included in the leaflet which was created by Canada Health ServicesAuthority when I received my Letrozole.   ... View more

Just to share an article which was created by a HK hospital with which the cancer center combines western medicine (ie.chemo) and eastern medicine (ie. side effects handling) in treating cancer patients. I have used google to translate it from chinese to English except the chinese medicine prescriptions and acupuncture operation sites which google failed to translate. ******** Hot flushes is a Vosomotor symptoms, which reduce the central body temperature by expanding the blood vessels of the skin. Hot flushes may be caused by early decline of ovarian function due to chemotherapy, as well as the use of tamoxifen and aromatase inhibitors. When compared to patients taking Letrozole,  patients taking tamoxifen have more frequent and severe hot flushes. Although clinical available drugs such as Gabapentin, Venlafaxine, Progesterone and Paroxertine can alleviate hot flushes, we should also consider the side effects of the drug. Besides, Paroxertine interface with tamoxifen. In daily life, paying more attention to the following matters can also help to reduce the appearance of hot flashes: Understand what will stimulate hot flushes, such as eating spicy foods and hot drinks, and then avoiding them Reduce drinking coffee. Prohibit alcoholic beverages. Dressing should be layered, the inner layer is breathable and easy to perspire, and it can be taken off immediately in case of sultry environment. Keep your room cool while you sleep Bedding should be based on cotton. Pajamas should also be based on cotton or quick-drying materials. Based on chinese medicine literature, hot flushes occurs due to age, major illness, chemotherapy and drug damage to liver and kidney. Diet (for kidney and liver) Dried black fungus 30g, dried black bean 30g, proper amt of water, After boil, then turn to medium heat for 1 hour and drink Dried gogi berries , dried lily bulb , each of 30-60g, proper amount of white rice. Eat porridge. Walnut 20g, dried gorgon fruit 15g, dried lotus seed15g, proper amt of white rice. Eat porridge.   In addition to diet, keep your mind calm, avoid excessive mood fluctuations. As well, recommend to swim 2-3 times a week. It can improve the operation of blood and swimming in cool water can effectively reducing body temperature. Swimming is the best exercise option for hot flushes patients   ... View more