Hi all, This is my first post on here, regarding treatments for early breast cancer for patients. My mum has recently completed herceptin following surgery for her breast cancer - and was offered a new treatment that reduces the risk of recurrence. The medication is called neratinib (nerlynx) and I just wondered if anyone has any experience on this drug? I did some research on her behalf after discussion with the oncologist and found out that NICE have reimbursed this drug for all patients that are HER2 Positive & Hormone receptor positive, that have completed herceptin in the last 12 months, providing patients still had some disease present after surgery, if they had neo-adjuvant treatment. The data from the ExteNet trial suggests up to 50% relative reduction in risk of disease recurrence. The diarrhoea reported in the trial was high - but mum was told that it should be manageable if she takes an anti-diarrhoeal with treatment. It is also an oral treatment - so no IV, which is great for mum as she's quite active! I just thought I should share this information - for anyone who may wish to go back and have a discussion with their Nurse or oncologist. Below are the links for NICE guidance and Spc. https://www.nice.org.uk/guidance/ta612 https://www.medicines.org.uk/emc/product/10477/smpc Hope this is helpful. Thank you.
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