Hi, so I finally got my results back. After I’d ordered the test I found 70-80% people are expected to metabolise tamoxifen normally, (https://www.ncbi.nlm.nih.gov/books/NBK247013/) so if I’d found this before I likely wouldn’t have ordered the test but my sample had gone off anyway. As it turned out I am in 6-10% that are poor metabolisers. Based upon that and co-incidentally lining up with a visit to a breast surgeon at the Royal Marsden, they stated for me, it was tamoxifen or nothing based on my results, (although I can check this with oncology). For DCIS, tamoxifen is not routinely given, but due to the small invasive element they’d found, they’d recommended it for that. At my age, early forties, the surgeon said the alternative of an AI and ovarian suppression would impact my life. So that’s decided it for me, the result tells you how poorly you’d metabolise and mine was the poorest. For me, I am glad I checked prior to starting adjuvant therapy. This is in relation to my results - info via above link does also state that for poor metabolisers the dose can be doubled or more, with endoxifen measured. Or an AI used with ovarian suppression. The above link equally states that some studies do not think there is a genetic implication on metabolism of tamoxifen or look at other genes. So different opinions but it is something I found, followed up and these were my results. We are all different, hope sharing this is useful.
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