Hello, I have been on Letrozole for three years, it effects sleep and anxiety. I have started Zoloft but I am not really depressed but anxiety is bad. I feel weird I have hair loss from med too. I can get angry quickly.. I am not sure Zoloft is the best med for me, but I do know I will have to take something. You are not alone when it comes to mental issues coming with Letrozole. I have been on it for three years. I just moved to Minnesota to be close to my daughter so I am adjusting to that as well. I have also started taking Prolia injections for my bones. Who knows maybe I need to take a break.
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