Hi Ramade, I have been on this combo since August. It is working so far have a scan this week so don't want to tempt fate. As to being toxic , a nurse put the fear of god in me how awful this med would be.I would have so many mouth ulcers I would be eating through a straw, i wouldn't be able to work , doom and gloom all round. Well, no real mouth ulcers to speak of, still working . I have lost weight , but seem to have reached a point now.Nails a little brittle , but ok. Have been abroad twice with no probs. We all react differently . I think they tell us the worse scenario. It has honestly been fine , I just want it to keep working . Good luck M xxx
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