Anyone Else on Zoladex? Reactions?

Hi all, had my first Zoladex injection (oh the size of that flipping needle!!!) on Weds and was completely wiped out all day Thursday. Whilst it is not considered “normal” by most medics to react so fast, I think I did react to it, as I am very sensitive to hormones (hence my oestrogen-sensitive breast cancer). Anyone else reacted fast to it? And what are the long-term reactions like? Is it all menopausal-type tiredness and weepiness and generally being incapacitated, or does it get better over time? Your experiences welcomed, please write!

Love and light,
Angel153

Ok so today I was planning to go out for the first time since the op, aside from hospital and doctors’ visits, to Burghley horse trials (I was an active “horse-whisperer” before all this kicked off, and part if my degree is equine sports science), but woke up feeling like crap. Fell asleep for most of the rest of the morning, then at 1.30pm suddenly burst into tears and just could not stop. BF was fantastic, and decided that getting me into the shower and washing my hair and making me feel better might helpl, then cooked me some lunch, but I have been howling pretty much all day.

Has this happened to anyone else on Zoladex? Does the first injection cause the worst reaction - does it get better over time, or does it get worse? I’m never going to get through my final degree year if it stays like this or gets worse, I’ve been utterly unfunctional all day. I find it irritating, pathetic and frustrating, it makes me feel so helpless and useless. I’m assuming this is because of a sudden drop in oestrogen caused by the Zoladex - it felt like a hormone wave of emotion to me, it certainly wasn’t attached to anything other than being a bit disappointed that I wasn’t well enough to go to Burghley and see friends there. Having had a life time of disrupted hormones, I have experience of hormone-depression vs reactive depression, and it was certainly a hormonal response that I’ve had today. It’s just a massive wave that completely engulfs you.

Anyone else experience this sort of thing with Zoladex?

Thanks,
Angel.

Oh great, i should be getting my first one on Thursday and im already thinking that im going to be growing a beard by the end of the day!!

Tracey
xxx

Hi girls

I was fine on zoladex until about 18 months down the line. Started to experience awful dizziness - felt like I was going to fall over all time. It lasted a few days then disappeared until the next injection - coincidentally it nearly always occurred when I had the injection on my right side. Never saw the needle until my last one - OUCH! So pleased about this as I think I would never have gone through with it. My GP was wonderful though, never felt a thing, never had any cream and only a little bruising.

Me personally could recommend Zoladex to everyone but then again we are all different and react in different ways.

And no, not hairy at all, just a little more “dippy dora”.

Love K

Hi all

I had my 2nd Zoladex a week ago… Didn’t really notice any side effects from the first jab but have been suffering from hot flushes for the last week or so. I now have a fan in my bedroom and a “chillow” on order as they are worse at night.

I felt a bit down yesterday evening/last night but I think that may have been Sunday night blues… I haven’t felt tired, weepy or dizzy yet and I never look at needles! I’m a big wimp and look in the other direction :slight_smile:

As Kelly says, I’m sure it all affects us in different ways but I would definitely be talking to my doctor if it was giving me those kind of effects Angel.

Jo x

Thanks girls, your nearly putting me at ease.

Tracey
xx

I had my first Zoladex 2 weeks ago. I have noticed I’m more emotional than I was (and I was bad enough then!!). Other than that, not too bad.

Haven’t grown a beard, but I do have a fantastic 3x2 inch bruise at the injection sight! Nice – not!

Does the pellet they put just under the skin disintegrate over the month? It does turn my stomach a bit when I touch it and can feel the pellet, I must admit.

I used the local anaesthetic cream and it did help although I felt the injection go in.

Not as bad as I was expecting though…

love,
Jacki xx

Hi girls, I can’t emphasise enough, my GP was adamant that you must NOT consider the 3 monthly Zoladex injection, this is only intended for men with prostate cancer, it works in a completely different way for women with breast cancer as it can’t guarentee that it will last for the whole 3 months, hence a risk of estrogen getting back into your system to feed the dreaded BC. Its only licenced, or meant to be anyway, for 1 month for BC patients. Sorry if I sound headstrong, but I feel quite high-horseyfied (if that is an identifiable word) that us women fighting this horrible disease do all we can to get the best possible outcome.

Love K

Hi all, saw GP Mon, and he says all this crying is entirely normal reaction to Zoladex, and that he’s lost count of thw women who have come to see him after the first one saying “I am NOT having any more of THAT!” He always persuades them to continue, he says the reaction to it gets less severe. Have had several more crying spates - is truly hideous, all in manner of heart-broken teenager, real big wrenching sobs, horrible.

Re Dippy Dora-ness - oh tell me about it! Rang dentist on Mon, explained about chemo starting on Fri and need to get three little chips out of my teeth fixed before chemo, and they said - I’m SURE they said - come in tomorrow, ie Tues. So off we toddled yesterday at 2, whereupon the receptionist said, “Are you sure it’s today? Only I don’t see how it can be, because the dentist doesn’t get back from lunch til 3 on Tuesdays…oh look, you’re in the book for Wednesday.” D’uh.

GP also said, pretty much, we’re giving you this, and the rest, to stop you from dying, so get a grip and get on with it, however awful you feel in the next few months, it’s better than the cancer killing you off. I said something along the lines of “Yes, with all the chemo, Zoladex, Tamoxifen and rads, my survival chances go up to 89%, which is good,” and he said “Yes, as long as you aren’t in the 11%.” !!! I could have done without that comment, I think.

Also, for everyone worried about getting hairy - it’s actually too much oestrogen and too little progesterone that causes the hairiness we all dread (that and sometimes too much testosterone in comparison to the other sex hormones). In theory, reducing oestrogen should reduce hairiness, but only if progesterone levels stay comparitively higher. The body reads relative levels, so no matter how low your oestrogen goes, as long as you have even less progesterone, the body will reckon it has too much oestrogen and produce those charming bristles! I know all this because this has been the state of my hormones for years, and I worked alongside a private doctor for a while who dealt with thyroid and adrenal and other hormonal probs, and did a lot of his research for him. If you read any of the John Lee books (Natural Progesterone, What Your Doctor May Not Tell You About Breast Cancer, and others), it explains it all in there.

I’ve already asked my GP to officially ascertain if I can continue using my progesterone cream whilst on Zoladex - I don’t see how it can do anything other than benefit, because of its oestrogen balancing effects (its “unopposed oestrogen” ie oestrogen without enough progesterone to balance it that drives our oestrogen +ve cancers, which my BC is), and he’s going to find out the official word on it. The progesterone also helps with the crying. (if any of you have non-cancer mates who have alwful PMS with swollen boobs, bloating, headaches, crying, rages, etc, it helps 100% with that, because those are all oestrogen-dominance signs too). And by the way, the much touted Wild Yam cream, Mexican or otherwise, does NOT convert to progesterone in the body, and is a total waste of money. Synthetic progestins do NOT work in the same way as natural progesterone either, the ONLY kind of progesterone that works is natural progesterone USP. See John Lee books for details.

I’ve had another reaction to the Zoladex too - which may be due to my BF insisting on feeling whether he could find the implant under my skin with his fingers - the injection site has got very inflamed, so GP’s given me fucidin-H (antibiotic + hydrocortisone) to put on. Am having better results with good old Tea Tree!

Kelly100 - sounds like your GP has his head screwed on right, I agree totally not to go with the 3 month one, far too much chance of oestrogen bouncing up again.

Thanks for all the replies, it does help hearing other people’s expeiences.

Love,
Nicola x

Hi to you all

I had my first Zoladex in July this year, and I was prescribed the 3 month one, now having read Kelly100’s comments this worried me.

I rang the helpline on this website and they told me the 3 month injection is totally safe and it is a slow release so you are fully protected, so now I am really confused. Why are some of us on 1 month and others on 3 monthly?

I am due my next one just before my next appointment with my Onc, so don’t know whether to delay it till after I have had a chance to speak to someone, or will that do even more harm.

I would appreciate any comments that will help put my mind at rest, as my tumour was extreemly hormone receptive.

Thanks, Deborah.xxx

Hi Deborah

Just posted again to you, but don’t know if it got sent. Please DON’T do the 3 monthly injection. Go to the Zoladex website and it will explain it there, also if you get the Zoladex injections from your pharmacist read the information leaflet. I will try and find my old leaflets and will get back to you.

If you are very oestrogen postive please play safe and have the monthly injection - apparently the 3 month one may not last the whole 3 months and then you have the risk of some oestrogen getting back into your system - the whole point of this injection is to stop that happening. Give me a few minutes and I will try and find my infor.

Love K

Thanks Kelly

Love Deborahxxx

Hi Deborah

Just found this on the net, still looking for my Zoladex info sheet but here’s just a little something for now:

“It is available as a 1-month depot and a long-acting 3-month depot. Both depots are used for the treatment of prostate cancer, endometriosis and uterine fibroids but only the 1-month depot is approved for breast cancer, endometrial thinning and assisted reproduction”

If I find anything more I will post it on here. Are you looking too:-)

Love K

Hi all, i just had my first Zoladex today, but i’ve had to have the three months due to being away as i would have had to miss half a month, and my onc said that that was far too long, but he also expects the gyni to have my ovaries out before the end of this year, but i have to see my onc two days after i get back from hols to check how i’m doing on it. 50 days of tomaxifen, at least i never have to take that again!!!

lots of love

Alisonxxx

Thanks for raising this Angel153.

I have just seen onc today and will have first injection tomorrow morning.

His registrar queried monthly or 3 monthly as he wrote the prescription. Onc said 3 monthly don’t work as well.

Guess I’ll just have to turn away so I don’t see the size of the needle!
Love
Mabel

hi Mabel had my first one today and it wasn’t so bad, its been about 9 hours now, ok, a bit of a bruise, but it feels fine, got my first real hot flush at about 7pm, it felt great!!

lots of love

Alisonxxxx

ps, i had the three month due to being away on holiday when the next is due

I finished 2 years of zoladex injections in June. The side effects did settle down after a few months but didn’t go away completely. I was lucky not to experience too much in the way of emotional side effects but I did get tired and have hot flushes. They were worse the week after the injection. I was given anaesthetic cream to put on before and I found the longer I left it on (up to 2 hours) the better. I also found that it hurt (even with the cream) if I had the jab on the left side of my tummy so I look like a pin cushion on my right side. It felt like the implant was going into muscle rather than fat and I think this is why it hurt. I still get hot flushes but that’s thanks to the tamoxifen. I haven’t had a period yet - I’m hoping that won’t happen (I’m 50). My onc says they’ll test for the menopause after a year if I’ve not had one by then. I don’t know if you saw in the papers a few months ago about a report in the Lancet of results of reseach into zoladex and tamoxifen. Apparently the benefits of this combination are as good as chemo and tamoxifen in pre menopausal women with oestrogen dependant tumours.
good luck to you all
fantan

Hi i haven’t had any pain where the needle went in, just think that could be cos of the nice layer of fat that now surrounds my midriff, found the local anesthetic more painful than the actual injection, got a bit of bruising but thats it

Alisonxxxxxxx

Hi all

Had a local before the implant too, agree with Alison that was the only pain.
I am quite bruised, had injection Friday it’s now Sunday, but still no hot flushes!

Hoping it’s just that it’s going to take a week for my side effects too as I am a bit anxious NOT to be having tropical moments yet!
Take care all
Mabel

Hi Mabel, lets hope you don’t get any, you might be one of these really lucky people who just go through the menopausal symptoms with no problems at all, but i have to say, i feel great even with the hot flushes, tomaxifen really didn’t agree with me.

lots of love

Alisonxxxxxx