Break in Abemaciclib?

Hi my fella Abemaciclib friends, i am interested to know if those of you who are on this med has ever been given a break? Appreciate your feedback. Thanks,

I experienced a lot of side effects on the 150mg × 2 so was told to take a 2 week break and the dose was lowered to 100mg when i restarted which has been fine so far x

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Yes I have had a number of breaks since starting Abemaciclib 9 months ago. Started on 150mg 2x day. First break after a month because of side effects, for 1 week, then started on 100mg 2x day. Second break for a week, after 2nd month because of elevated liver enzymes and low white blood cell count. And for the last 4 months I’ve been on for 8 days and off for 5 days due to try to keep my liver enzymes and platelets in a near normal range. My onc has suggested dropping me to 50mg 2x day, but that hasn’t been necessary yet.