Changing side effects of Leuprorelin?


I was diagnosed with early stage breast cancer in July 21. Had a mastectomy, chemo, radio and then started Leuprolelin in about May 22 I think. I’ve been receiving 3 monthly injections since.

I had been handling the drugs fairly well but about 3 weeks before the last injection, ended up feeling quite emotional and sleeping terribly. (Work is also stressful so thought it might be a one off.) Now in the 3 week period before the next injection and it seems to be happening again… ?

Can the side effects of the drug change over time? 

Hi CurlyGirlie    

Thanks for posting asking about side effects of leuprorelin

It’s difficult to say why you are feeling more emotional and having difficulty sleeping in the last few months and whether it is due to your leuprorelin.  You don’t mention from your post if you are taking a hormone therapy alongside your injections, but some people find that they can experience different side effects in the months and years that they are taking them.  

You also mention that work is stressful so this may also be affecting your sleep and impacting on how you are feeling emotionally. I wonder if you’ve discussed these difficulties with your line manager, They may be able to help make reasonable adjustments to make your work less stressful. 

If you haven’t already done so, do let your breast care nurse, treatment team or GP know how you are feeling so that they can assess your symptoms.  

Adapting to life after treatment can be difficult and often the need for information and support continues. You may be interested in our resources that are particularly for those who have come to the end of their main hospital treatment. These are known as our Moving Forward services and include our Moving Forward booklet and Moving Forward courses.  

We also offer a range of free supportive services that you may be interested in.  

We are currently evaluating this service and would appreciate your feedback. Please click here to the survey. It should take approximately 10 minutes to complete.  

Do call our helpline if you would like to talk this through or have any further questions. The helpline team have time to listen to your concerns, talk things through and signpost you to more support and information. Your call will be confidential, and the number is free from UK landlines and all mobile networks. The number is 0808 800 6000, (Relay UK -prefix 18001). 

If you would prefer one of our nurses to call you. To do this, please complete this form t** icking the box agreeing to a call back.** 

Our usual opening hours are Monday to Friday 9am - 4pm and 9am -1pm on Saturday.  

Out of hours you can leave a message and we will call you back when we next open.  

Best wishes 


Breast Care Nurse 

Please read the Ask Our Nurses disclaimer  Full details on how we collect and use your data can be found in our Privacy Policy  

This thread will now be closed from further replies. If you have any additional questions or would like to provide feedback, please start a new thread.