Classical LCIS E-cadherin is negative

Diagnosed with breast cancer DCIS/LCIS
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I’ve requested by pathology results and there is additional information on there. ‘E-cadherin is negative confirming Classical LCIS’. The classical LCIS was not mentioned to me. I also have Grade 1 ductal cancer and DCIS in the same breast. Anyone have experience of this?

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Hi yes my results are similar. Mixed ductal and lobular invasive cancer and also LCIS and DCIS

Really wasn’t expecting those results, I hoped surgery , radiotherapy and hormone treatment would be enough but I am going to need chemotherapy etc now too. How are you getting on?

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Hi. Thank you for your response. I have only just seen your reply so apologies for the late response. I am now on the other side of everything.I also had grade 2 invasive ductal cancer in my other breast. I Was diagnosed exactly 7 months ago. Following a lumpectomy, the margins were not clear. I have now had a double mastectomy with reconstruction. How are you getting on?

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I have had my surgery ( WLE) and am going to start chemotherapy on Friday. Not looking forward to it I must say. Unfortunately there is a high chance of distance recurrence ( secondary cancer) so they want me to have everything. I was so disappointed as until the pathology results came through I thought it was radiotherapy and hormone tablets for me .. really hoped to avoid chemotherapy but here I am.:zany_face: I hope you will be ok . Really interested to hear x

1 Like
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I sincerely wish you the best during this time. Remember that you are not alone, even though that’s how it may feel. The forum is a great support xx :heart: Just reach out x

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Thank you. I wish you all the best too.

I was initially going to have just a lumpectomy which would have left me very lopsided. I also have MS so they wanted to keep the surgery as simple as possible. The surgeon explained again on the day about the lopsided outcome and I must have looked sad because he said I’d be taking a big risk but if I really wanted he would do a reduction on the other breast at the same time, which was fantastic. It took a while ( including being allergic to the dressings) but I have healed. How are you doing after your surgery as it sounds more complicated than mine?