Hi ladies
i have been taking letrozole and palbociclib and denosumab since March this year - SE of hair thinning (now stopped) and the achy joint thing.
However for the last 3 days have had really upset tummy (bloating, pain and the can’t stay far from the loo kind 
)
Haven’t had anything to eat that I would think may have triggered and wouldn’t expect to be like this after 3 days if I had.
Has anyone experienced delayed SE? Am wondering if this can happen?
Thanks
Di x
Hi Di, sorry you are feeling a bit shabby. From what I understand SEs with these drugs don’t always happen immediately but occur after some time as there is a cumulative effect in the body. I’ve been on Letrozole and Palbociclib for two years and after chugging along nicely I’m now experiencing similar symptoms to you, plus joint pain. I’ve narrowed the tummy bit down to white bread and pastry. Also sweet corn and chillies now repeat at both ends… tmi ?. I’m going to ask my Onco for a little holiday from my meds at the next clinic. Hopefully that will sort it. Sick of planning my shopping around loos!!! X