Docetaxel sensitivity

Going through breast cancer treatment Chemotherapy
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Hi all

I have been browsing re this but couldn’t so decided to start a new topic.
I just got back from my third cycle of TCHP (neo-adjucant for grade 2 triple positive breast cancer). I had a reaction to the second infusion of docetaxel but it was stopped, managed and resumed at a lower pace cycle two. I have been unwell since. Cycle 3 was delayed twice due to a chest infection and breathlessness which then became a sensitivity to two different antibiotics, CT scan looking for lung fibrosis and then another looking for thrombosis. All negative.

Cycle 3 happened today and what ended up going through was CHP as I had another reaction to docetaxel even at the slower pace possible and it had to be stopped. I have now been told that the oncology team will be in touch to talk about my plan going forward.

I am so deflated today: feel like every visit to the hospital raises more questions and complexities than any source of relief or feeling of progression. Has anyone been in a similar position and if so, what can be done to tackle this sort of situation? Should I be pushing for anything in particular? Very aware that I am not the medical professional but do feel that time passes and although the treatments are on pause and revised, the cancer itself isn’t paused.

Many thanks

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Sorry to hear there are curveballs to your treatment

I also had a reaction cycle 2 which they stopped, gave me more steroids & slowed the infusion down

For cycle 3 (and 4) I had a very strong antihistamine added to my pre meds

Had a mini reaction cycle 3 and arm blue up too (had a cannula) but was “ok”

Not sure if this is being given?

I know what Docetaxel can be replaced by Abraxane but unsure if this is also ok on TCHP

I was on TC

May be work asking ?
Xx

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Thank you so much. This is very helpful. My reaction from cycle 3 yesterday sounds a lot like your one, including the blue arm. Will get in touch with my team over the weekend to see what they suggest. Xx

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Hi, I just wanted to say that I am on ECT chemo and had a reaction to paclitaxel after which I was changed to Abraxane which I have been fine on, & by all accounts is generally very well tolerated.
Of course, I have no idea whether this is conceivable on TCHP chemo but what I do know is Abraxane is very costly & they don’t exactly dish it out unless they absolutely have to. So definitely one to advocate for if at all possible.

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Hi
I had the same reaction during the start of 2nd Docetaxel. They gave me iV antihistamine and slowed the dose. This worked really well. It made me very sleepy for next 2 days but I was grateful for that. I then insisted each time that I was given antihistamine - they said I did not probably need it, but I said I would not want to have the chemo without it. Hope that helps. I’m sure they will find a solution for you - there are so many options. Sending hugs your way x

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