Hello,
I’ve had one round of Kadcyla and 10 out of 15 radiotherapies. I’ve got sore fingertips and a watery eye, which I think is from the Kadcyla. However, I’m also getting headaches and lower back ache, and am wondering if this is from the radio or the Kadcyla. (The Kadcyla is for the primary BC that I had btw, not secondary). Any ideas from those of you who’ve been through both??? TIA
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Welcome to the forum . Hopefully someone who’s been through this combination will comment ,I don’t think there are many people as yet on this treatment for primary breast cancer .
I had radiotherapy I would say fatigue and obviously a very red and sore breast would be the main symptoms people experience .Headache could maybe also be related to radiotherapy due to dehydration ? You could also ask about Kadcycla side effects specifically in the secondary section of the forum and the Ask the Nurses section .
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Thank you. I think it’s mainly used for those whose primary cancer is Her2+ and there’s some residual cancer left after chemo and surgery. The list of possible side effects for Kadcyla is pretty extensive as it contains chemo, so it’s tricky to decipher!
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I’m HER2+, primary breast cancer and I have just finished my 6th Kadcyla; after each round I have had headaches lasting for a couple of days, I also got sore fingertips (the skin peeled away so easily). No watery eye, but a strange pain behind my ears, not sure if this was due to the Zoledronic acid infusion I had straight after my 5th Kadcyla. I had 20 sessions of radiotherapy and didn’t have headaches or back ache with this, just a bit sore.
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Thank you for responding. The back ache and headaches come and go and seem to be manageable by paracetamol. The sore fingertips are a pain though and make it tricky to do everyday tasks, like opening a bottle or pulling out a load of washing. Did you find anything to help this?
I also managed the headaches by paracetamol, as for the sore fingertips, I just used Savlon and they eventually got better (although my skin is very thin still). It was a pain trying to do things, sorry I can’t give any better advice!
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Hi, I am 9 cycles into Kadcyla and had 5 sessions of radiotherapy but not at the same time. I found radiotherapy uncomfortable due to holding arms above the head, made my back a bit sore. I have had very few side effects from Kadcyla and yes I have very watery eyes, however, that started whilst I was on the Docetaxil Carboplatin Phesgo combination so not caused by Kadcyla. Fingertips and toes are a little numb but again that all began before I started Kadcyla. Hope you side effects improve soon. Best wishes. X
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Hello and thank you, I too had the watery eyes and sore fingertips with Docetaxel & Carboplatin, but my last one was 26th May, so I assumed they would be out of my system by now. I know the Kadcyla contains some chemo, so I’m wondering if it’s because of that. To be honest if these are the worst symptoms I’m sure I can manage. So long as my taste doesn’t go horrible and my hair doesn’t fall out again!!!
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I finished my first lot of chemo at the end of November so I don’t think the watery eyes is to do with that but more about the loss of lashes. Am using a serum at the moment to try to thicken them up. I have not got the horrible taste with Kadcyla and my hair is thicker than before, so fingers crossed for you. X
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My lashes are growing back. Did you lose them again with Kadcyla? I’ll be gutted if mine go again! 
No, didn’t lose them again they are just taking a time to fully grow back and the lashes are very fine. That is what I am hoping and that I do not have to live with runny eyes forever. X
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Oh I see. My lashes are well on their way yet I still get the occasional runny eye - just the one. Is a lottery isn’t it (a really rubbish one)?
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Hi
I had 6 cycles of docetaxel & carboplatin, plus Phesgo. Lost my eyelashes, very watery, sticky eyes. 3 months later (post ops) just started my Kadcyla regime.
During these 3 months my eyelashes are 50% back (length) & watery/sticky eyes no longer an issue. So far so good with Kadcyla, long may it last.
Good luck & hope the slow regrow of lashes solves gets u back to normal. Ana x
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Hi Everyone
I seem to have had the same treatment for HER2+ breast cancer
6 rounds of Doxy/Carbo
Surgery inc auxiliary clearance on the left
I was on Phesgo and now on Kadcyla, awaiting 15 sessions of radio therapy.
I also have the same symptoms… watery eye, back pain, general joint aches (especially elbows?) and nausea which I haven’t had before.
I’m about to have round 3/14 of Kadcyla and they are not stopping for radiotherapy.
Anyone further down the line that can tell me how they are getting on?
Would love to hear from you. Kadcyla doesn’t seem that common a treatment
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Jumping on the back of all your posts.
I too am Her2 pos primary BC.
Had x6 DC with phesgo .
Had a lumpectomy with 3-5mm vlearance All but 0.7mm disdolved aroubd the magseed.
Total pathological response in the 2cm node ander the arm.
Phesgo changed to Kadcyla because of the 0.7mm ( Katherine Trial)
Just had my first of 12 on Wed. . ive just had my radiotherapy planning scans ready for 15. Doibg roughly at the same time/ weeks about.
I did have bad side effects from DC ( given 80%) some neuropathy in left foot and fatigue , a watery eye for the last cycle… so very similar to some of you.
Kafcycla side effects came in on day 5 and im still wiped out day 7… stomach pain, body aches and chills , tender throat , lower back pain joint aches…
I took Ondanestron as i am emetophobic and got constipation. Started the laxido too late!
My question…
anyone else take antiemetics with Kadcyla
what do you take / how often?
Thanks do much in advance.