Letrisole and vagirux

Having had months of uti/bladder issues my oncologist has suggested staying on Letrisole but to take Vagirux (10mg estradiol). I’m worried this is putting me at risk of reoccurrence as I’m effectively taking oestrogen and my cancer was ER +. Is the risk so low that I don’t need to worry?

Hello Rainbow54

Thanks for your post. It’s natural to ask if taking vaginal oestrogen when you’re diagnosed with breast cancer that is sensitive to oestrogen will increase your risk of a cancer recurrence.

Vaginal dryness and bladder problems, together with other menopausal symptoms, are common in women who have had or are having treatment for breast cancer. This is because some breast cancer treatments block or reduce the amount of the hormone oestrogen in the body. Oestrogen helps keep the vagina’s moisture and elasticity. A lack of it can cause the vagina and the surrounding tissues to become dry and less supple, causing pain, soreness and sometimes urinary tract infections, as you have experienced.

The most commonly used treatment for vaginal dryness is HRT (hormone replacement therapy). HRT is not usually recommended for women after a diagnosis of breast cancer. However, as in your case, some specialists will consider prescribing hormone treatments that are applied directly to the vagina (topical or vaginal oestrogen). These include oestrogen pessaries, creams or a ring.

Some small studies suggest that vaginal oestrogen is considered safe and does not increase the risk of the cancer returning, as it is only absorbed locally to the vagina.

Pelvic floor exercises can also help improve vaginal dryness by increasing blood flow to the area. The links above will direct you to our information and give suggestions which may help.

Some people may also benefit from a referral to a physiotherapist specialising in pelvic problems caused by post breast cancer treatment menopause, including vaginal dryness and bladder problems. Referral to a specialist menopause clinic may also be an option.

It’s important that you discuss your concerns with your breast care nurse, treatment team or GP. They may be able to refer you for some talking therapies to help you through this difficult time

Our booklet Your body intimacy and sex booklet also has information, which may be of interest.

We offer a range of free supportive services for anyone who has had a diagnosis of breast cancer which you may be interested in. They include face to face and online courses and events.

You’re welcome to call our helpline if you would like to talk this through or have any further questions. The helpline team have time to listen, talk things through and signpost you to additional support and information if necessary. Your call will be confidential, and the number is free from UK landlines and all mobile networks.

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Best wishes

Addie

Breast Care Nurse

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